SML2516

Valrubicin

• 别名: Trifluoroacetyladriamycin 14-valerate
• 经验公式（希尔记法）: C₃₄H₃₆F₃NO₁₃
• CAS号: 56124-62-0
• 分子量: 723.64
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 形狀: powder or crystals
• 儲存溫度: 2-8°C
• InChI: 1S/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14?,17?,19-,22?,27?,33-/m0/s1
• InChI 密鑰: ZOCKGBMQLCSHFP-ZQUOIQDWSA-N

说明

生化／生理作用

Valrubicin is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. Valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA and causing cell cycle arrest.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H340,H350,H360F
• 防範說明: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• 危險分類: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable