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化驗
≥98% (HPLC)
形狀
powder
顏色
white to brown
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
SMILES 字串
N(c2cc3nc([o]c3cc2)c4ccncc4)C(=O)\C=C\c1[o]ccc1
InChI
1S/C19H13N3O3/c23-18(6-4-15-2-1-11-24-15)21-14-3-5-17-16(12-14)22-19(25-17)13-7-9-20-10-8-13/h1-12H,(H,21,23)/b6-4+
生化／生理作用
SW157765 is a selective inhibitor of the non-canonical glucose transporter GLUT8 (SLC2A8), which exhibit potent anticancer activity on KRAS/KEAP1 mutant NSCLC cells that selectively depend on GLUT8 for glucose intake to support serine biosynthesis.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Elizabeth A McMillan et al.
Cell, 173(4), 864-878 (2018-04-24)
Diversity in the genetic lesions that cause cancer is extreme. In consequence, a pressing challenge is the development of drugs that target patient-specific disease mechanisms. To address this challenge, we employed a chemistry-first discovery paradigm for de novo identification of
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