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Merck

SML1114

Sigma-Aldrich

IWP-4

≥95% (HPLC)

别名:

N-(6-甲基-2-苯并噻唑基)-2-[[3,4,6,7-四氢-3-(2-甲氧基苯基)-4-氧噻吩并[3,2-d]嘧啶-2-基]硫代]-乙酰胺

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About This Item

经验公式(希尔记法):
C23H20N4O3S3
分子量:
496.62
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

顏色

white to light brown

溶解度

DMSO: 0.5 mg/mL, clear (warmed)

儲存溫度

−20°C

SMILES 字串

O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5

InChI

1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)

InChI 密鑰

RHUJMHOIQBDFQR-UHFFFAOYSA-N

生化/生理作用

IWP-4 是 Wnt 通路调节蛋白 Porupine(Porcn)的有效抑制剂。 IWP-4 阻断棕榈酸酯化以及随后的 Wnt 分泌和活性。 IWP-4 诱导人多能干细胞分化为心肌细胞。
IWP-4 阻断 Wnt 家族成员 5a。它阻断 Wnt 蛋白分泌,并阻断经典和非经典信号通路。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Here we provide a protocol for the directed differentiation of hEPI-NCSC into midbrain dopaminergic neurons, which degenerate in Parkinson's disease. hEPI-NCSC are neural crest-derived multipotent stem cells that persist into adulthood in the bulge of hair follicles. The experimental design
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Over the last decade, Organ-on-Chip (OoC) emerged as a promising technology for advanced in vitro models, recapitulating key physiological cues. OoC approaches tailored for cardiac tissue engineering resulted in a variety of platforms, some of which integrate stimulation or probing

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