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Merck
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Key Documents

SML0929

Sigma-Aldrich

HS38

≥95% (HPLC)

别名:

2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]-propanamide, 2-[[1-(3-Chlorophenyl)-4-oxo-5H-pyrazolo[5,4-d]pyrimidin-6-yl]sulfanyl]propanamide

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About This Item

经验公式（希尔记法）:
C14H12ClN5O2S
CAS号:
1030203-81-6
分子量:
349.80
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

2-8°C

生化／生理作用

HS38 is a potent and selective ATP-competitive inhibitor of Death-associated protein kinases DAPK1 (IC50 = 200 nM, 89% inhibition at 10 RM) and ZIPK (Zipper-interacting protein kinase, also called DAPK3) that regulate programmed cell death, and also inhibits the closely related PIM3 kinase (IC50 = 200 nM, 76% inhibition at 10 RM). In addition to mediating apoptosis, DAPK1 and ZIPK regulate both non-muscle and smooth muscle myosin phosphorylation. HS38 specifically targeted ZIPK in smooth muscle, and decreased contractile force generated in mouse aorta, rabbit ileum, and calyculin A stimulated arterial muscle.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Yu Guo et al.
Molecular neurobiology, 56(5), 3368-3379 (2018-08-19)
Loss of memory is an inevitable clinic sign in aging, but its underlying mechanisms remain unclear. Here we show that death-associated protein kinase (DAPK1) is involved in the decays of learning and memory in aging via degradation of Caytaxin, a

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