推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -36 to -46°, c = 1 in methanol
儲存條件
desiccated
顏色
white to beige
溶解度
H2O: 20 mg/mL, clear
儲存溫度
−20°C
SMILES 字串
Cl.[n]1(c2c(c(c1)C(=O)[C@@H]3CCc4nc[nH]c4C3)cccc2)C
InChI
1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
InChI 密鑰
XIXYTCLDXQRHJO-RFVHGSKJSA-N
生化／生理作用
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists.
Ramosetron hydrochloride is a potent serotonin 5-HT3 receptor antagonist with higher afinity for the 5-HT3 receptor than other currently available antagonists. Ramosetron is used clinically both as an antiemetic to treat nausea and vomiting following chemotherapy or after surgery, and in treatment of irritable bowel syndrome.
Ramosetron is a tetra hydrobenzimidazole derivative, containing an indole ring. It inhibits colon contraction mediated by serotonin, competitively.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Youn Yi Jo et al.
Surgical endoscopy, 26(8), 2306-2311 (2012-02-24)
In this randomized and controlled study, we evaluated the antiemetic efficacy of ramosetron combined with dexamethasone for postoperative nausea and vomiting (PONV) compared with that of dexamethasone or ramosetron alone in women who underwent laparoscopic cholecystectomy. One hundred twenty female
Takahiro Mihara et al.
Anesthesia and analgesia, 117(2), 329-339 (2013-06-13)
Ramosetron has been shown to have a very strong effect for preventing postoperative nausea and vomiting (PONV) in previous meta-analyses. However, these previous meta-analyses included a number of studies by Fujii et al. which have now been proven to have
Ramosetron might be useful for treating diabetic diarrhea with a rapid small bowel transit time.
Tae Hee Lee et al.
The Korean journal of internal medicine, 28(1), 106-107 (2013-01-25)
Matching groups for studying postoperative nausea and vomiting: should we care?
Boris Mraovic et al.
Surgical endoscopy, 24(7), 1796-1797 (2010-01-02)
Eun Young Park et al.
The Journal of international medical research, 41(3), 654-663 (2013-05-11)
This randomized, double-blind study compared the antiemetic efficacy of ramosetron with that of ramosetron combined with midazolam, and investigated whether the timing of midazolam administration affected the incidence of postoperative nausea and vomiting (PONV). Nonsmoking female patients undergoing laparoscopic gynaecological
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