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Merck
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主要文件

SML0649

Sigma-Aldrich

脱羟基 LY-411575

≥98% (HPLC)

别名:

γ-Secretase inhibitor XX, (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine, GSI-XX, N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide, YO-01027

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About This Item

经验公式（希尔记法）:
C26H23F2N3O3
CAS号:
209984-56-5
分子量:
463.48
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D -128.0 to -154.0°-0.25 in methanol

顏色

white to beige

溶解度

DMSO: 15 mg/mL, clear

儲存溫度

−20°C

InChI

1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1

InChI 密鑰

QSHGISMANBKLQL-OWJWWREXSA-N

應用

Deshydroxy LY-411575 has been used in dibenzazepine (DBZ) treatment and chemical treatment.

生化／生理作用

Deshydroxy LY-411575 is a cell-permeable γ-secretase inhibitor and inhibtor of Notch processing. Deshydroxy LY-411575 significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model and potently blocks Notch processing, with an IC50 of 1.7 nM in SupT1 cells.
LY411575 prevents SPP (signal peptide peptidase) dependent cleavage of HCV (hepatitis C virus) core protein.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302,H317

危險分類

Acute Tox. 4 Oral - Skin Sens. 1A

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Qiuping He et al.
Experimental hematology, 51, 1-6 (2017-05-01)
During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) after their emergence in the aorta-gonad-mesonephros (AGM) region. We recently reported that the endolysosomal trafficking factor BLOS2, encoded by the Bloc1s2 gene, regulates HSC/hematopoietic progenitor
Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity.
Otoguro T, et al.
Microbiology and Immunology, 60(11), 740-753 (2016)
G protein-coupled receptor 183 facilitates endothelial-to-hematopoietic transition via Notch1 inhibition.
Zhang P, et al.
Cell Research, 25(10), 1093-1093 (2015)
Pooja Hor et al.
iScience, 23(5), 101083-101083 (2020-05-08)
Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity (<1% of total lung cells) and a lack of established protocols for their isolation.
Justin K Ichida et al.
Nature chemical biology, 10(8), 632-639 (2014-06-24)
The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of
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