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Merck
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文件

G1421

Sigma-Aldrich

GW405833 盐酸盐

≥98% (HPLC), solid

别名:

1-(2,3-二氯苯甲酰基)-5-甲氧基-2-甲基-(3-(吗啉-4-基)乙基)-1H-吲哚 盐酸盐, 242 盐酸盐, L-768, L-768242 盐酸盐, L768242 盐酸盐, ML-SI1盐酸盐

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About This Item

经验公式（希尔记法）:
C23H24Cl2N2O3 · HCl
CAS号:
180002-83-9
分子量:
483.82
MDL號碼:
MFCD09832650
分類程式碼代碼:
12352200
PubChem物質ID:
329799842
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

solid

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

儲存條件

desiccated

顏色

white to pink

溶解度

DMSO: soluble >10 mg/mL
H2O: insoluble <2 mg/mL

儲存溫度

2-8°C

SMILES 字串

Cl.COc1ccc2n(c(C)c(CCN3CCOCC3)c2c1)C(=O)c4cccc(Cl)c4Cl

InChI

1S/C23H24Cl2N2O3.ClH/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25;/h3-7,14H,8-13H2,1-2H3;1H

InChI 密鑰

JIQYDHDVNNFPMU-UHFFFAOYSA-N

應用

GW405833盐酸盐被用作溶酶体瞬时受体电位粘脂素1 (TRPML1)特异性抑制剂，以验证TRPML1是否介导神经元中tau蛋白的释放，并验证其是否介导溶酶体tau蛋白的释放。也用作TRPML通道阻断剂，以研究粘脂素瞬时受体电位阳离子通道3 (MCOLN3/TRPML3)功能和运输对海拉细胞自噬的影响。

生化／生理作用

GW405833是一种选择性的大麻素CB2受体激动剂；止痛药。 GW405833可以高亲和力结合人和大鼠CB2受体（Ki′s 3.9和3.6 nM）；充当部分激动剂（与完全激动剂CP55，940相比，对福司可林刺激的cAMP形成的抑制率为50％）。GW405833在炎性、神经性和切口疼痛的大鼠模型中具有有效的镇痛作用；缺乏CB1激动剂常见的CNS效应。
GW405833盐酸盐，又称ML-SI1，是一种细胞可渗透溶酶体瞬时受体电位阳离子通道、粘脂素亚家族(TRPML)阻断剂。

特點和優勢

《受体分类和信号转导》手册的大麻素受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301,H413

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 4

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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I Dando et al.
Cell death & disease, 4, e664-e664 (2013-06-15)
The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism of action remains unclear. We used cannabinoids specific for the CB1 (ACPA) and CB2 (GW) receptors and metabolomic analyses to unravel the
M Donadelli et al.
Cell death & disease, 2, e152-e152 (2011-04-29)
Gemcitabine (GEM, 2',2'-difluorodeoxycytidine) is currently used in advanced pancreatic adenocarcinoma, with a response rate of < 20%. The purpose of our work was to improve GEM activity by addition of cannabinoids. Here, we show that GEM induces both cannabinoid receptor-1
Charlotte Leser et al.
European journal of medicinal chemistry, 210, 112966-112966 (2020-11-15)
The members of the TRPML subfamily of non-selective cation channels (TRPML1-3) are involved in the regulation of important lysosomal and endosomal functions, and mutations in TRPML1 are associated with the neurodegenerative lysosomal storage disorder mucolipidosis type IV. For in-depth investigation
Bethan S Kilpatrick et al.
Journal of cell science, 129(20), 3859-3867 (2016-09-01)
Transient receptor potential (TRP) mucolipins (TRPMLs), encoded by the MCOLN genes, are patho-physiologically relevant endo-lysosomal ion channels crucial for membrane trafficking. Several lines of evidence suggest that TRPMLs mediate localised Ca2+ release but their role in Ca2+ signalling is not
So Woon Kim et al.
Autophagy, 15(2), 327-340 (2018-09-15)
MCOLN3/TRPML3 is a Ca2+-permeable cation channel that is expressed in multiple subcellular compartments with dynamic localization. Our previous studies suggest that upon macroautophagy/autophagy induction MCOLN3/TRPML3 is recruited and provides Ca2+ for the fusion process in autophagosome biogenesis. However, how intracellular

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