所有图片(1)
About This Item
经验公式（希尔记法）:
C10H7IN2
CAS号:
分子量:
282.08
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥97% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 10 mg/mL (clear solution, warmed)
儲存溫度
−20°C
SMILES 字串
Ic1cc(ncn1)-c2ccccc2
InChI
1S/C10H7IN2/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H
InChI 密鑰
ZTCJXHNJVLUUMR-UHFFFAOYSA-N
應用
在 体外 迁移测定中，4-IPP 已被用作条件培养基 (CM) 中的巨噬细胞的迁移抑制因子 (MIF)。
生化／生理作用
4- IPP是细胞渗透、有效的巨噬细胞迁移抑制因子（MIF）拮抗剂，共价修饰MIF的N末端脯氨酸。
4-碘代-6-苯基嘧啶 (4-IPP) 有可能成为一种新的抗多倍体治疗剂，可在甲状腺癌患者中用于靶向多倍体肿瘤细胞。它可通过阻断IMF-κB途径抑制破骨细胞的生成。4-IPP 可作为巨噬细胞迁移抑制因子 (MIF) 的治疗靶点，用于治疗病理性溶骨性骨病和绝经后骨质流失。它可以阻止肺腺癌细胞的发育和运动，并可以刺激甲状腺癌的细胞凋亡和有丝分裂死亡。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Nadège Kindt et al.
Journal of clinical medicine, 8(1) (2019-01-13)
Human papilloma virus (HPV) infection has been well-established as a risk factor in head and neck squamous cell carcinoma (HNSCC). The carcinogenic effect of HPV is mainly due to the E6 and E7 oncoproteins, which inhibit the functions of p53
Kavitha Yaddanapudi et al.
Cancer immunology research, 4(2), 101-112 (2015-11-26)
Highly aggressive cancers "entrain" innate and adaptive immune cells to suppress antitumor lymphocyte responses. Circulating myeloid-derived suppressor cells (MDSC) constitute the bulk of monocytic immunosuppressive activity in late-stage melanoma patients. Previous studies revealed that monocyte-derived macrophage migration inhibitory factor (MIF)
Deepa Rajasekaran et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(11), 4961-4971 (2014-07-13)
We report a new inflammatory activity for extracellular d-dopachrome tautomerase (D-DT), the recruitment of neutrophils to the lung on D-DT intratracheal installation of C57BL/6J mice with an EC50 of 5.6 μg. We also find that D-DT and macrophage migration inhibitory
Hiro Takahashi et al.
PloS one, 8(10), e78250-e78250 (2013-10-30)
The diagnosis and treatment of soft tissue sarcomas (STSs) has been particularly difficult, because STSs are a group of highly heterogeneous tumors in terms of histopathology, histological grade, and primary site. Recent advances in genome technologies have provided an excellent
Tali Lang et al.
Nature communications, 9(1), 2223-2223 (2018-06-10)
Macrophage migration inhibitory factor (MIF) exerts multiple effects on immune cells, as well as having functions outside the immune system. MIF can promote inflammation through the induction of other cytokines, including TNF, IL-6, and IL-1 family cytokines. Here, we show
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