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Merck

SML0445

Sigma-Aldrich

克立马丁 富马酸盐

≥98% (HPLC)

别名:

(+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine

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About This Item

经验公式(希尔记法):
C21H26ClNO · C4H4O4
CAS号:
分子量:
459.96
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +15 to +25°, c = 1 in methanol

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 5 mg/mL (clear solution; warmed)

儲存溫度

room temp

SMILES 字串

OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3

InChI

1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

InChI 密鑰

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

基因資訊

human ... HRH1(3269)

一般說明

Clemastine fumarate is used to treat multiple sclerosis, sneezing and rhinorrhea linked to common cold. It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.

應用

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.

生化/生理作用

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

特點和優勢

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Wafaa S Hassan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 69(1), 245-255 (2007-06-08)
Two rapid, simple and sensitive extractive specrophotometric methods has been developed for the determination of three histamine H1-antagonists drugs, e.g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations. The first method depend
Clemastine fumarate as a remyelinating therapy for multiple sclerosis (ReBUILD): a randomised, controlled, double-blind, crossover trial
Green AJ, et al.
Lancet, 390(10111), 2481-2489 (2017)
Murat Bas et al.
Annals of emergency medicine, 56(3), 278-282 (2010-05-08)
The pathophysiology of angiotensin-converting enzyme inhibitor (ACEi)-induced angioedema most likely resembles that of hereditary angioedema, ie, it is mainly mediated by bradykinin-induced activation of vascular bradykinin B2 receptors. We hypothesize that the bradykinin B2 receptor antagonist icatibant might be an
P Johansen et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 38(3), 512-519 (2007-12-18)
Histamine released from activated mast cells and basophils is an important mediator in allergy. Therefore, antihistamines are efficiently and widely used to suppress allergic symptoms. This study evaluated the role of antihistamines in sensitization against allergens and in the efficiency
Annica Tevell Aberg et al.
Rapid communications in mass spectrometry : RCM, 24(10), 1447-1456 (2010-04-23)
Cunninghamella elegans is a filamentous fungus that has been shown to biotransform drugs into the same metabolites as mammals. In this paper we describe the use of C. elegans to aid the identification of clemastine metabolites since high concentrations of

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