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品質等級
化驗
≥98% (HPLC)
形狀
powder
藥物控制
regulated under CDSA - not available from Sigma-Aldrich Canada
顏色
white to beige
溶解度
DMSO: 5 mg/mL (clear solution; warmed)
儲存溫度
room temp
SMILES 字串
CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI
1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
InChI 密鑰
UBRKDAVQCKZSPO-UHFFFAOYSA-N
應用
AF-DX 116 用作 M2 毒蕈碱受体（M2AChR）选择性拮抗剂，以研究 M2AChR 对年轻糖尿病大鼠齿状回基底和碳水化合物刺激长期增强（DG-LTP）的调节和海马细胞前神经生长因子（proNGF）分泌的影响。
生化／生理作用
AF-DX 116 可在反复冷应激诱导的低血压大鼠模型中升高血压和心率。因此，它可以治疗与迷走神经症型自主神经功能障碍相关的低血压。
AF-DX 116是一种选择性M2毒蕈碱乙酰胆碱受体拮抗剂。
特點和優勢
该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Julia B R Pfeiffer et al.
American journal of veterinary research, 68(3), 313-322 (2007-03-03)
To describe the in vitro effects of bethanechol on contractility of smooth muscle preparations from the small intestines of healthy cows and define the muscarinic receptor subtypes involved in mediating contraction. Tissue samples from the duodenum and jejunum collected immediately
S E McGowan
Respiratory physiology & neurobiology, 157(2-3), 281-289 (2007-02-27)
Vitamin A deficiency (VAD) remains an important problem in the developing world where environmental air pollution is increasing. Because the coincidence of these factors could increase the prevalence of asthma in these regions, airway reactivity to methacholine (MCh), capsaicin, and
Takio Kitazawa et al.
European journal of pharmacology, 554(2-3), 212-222 (2006-11-23)
Functional roles of muscarinic acetylcholine receptors in the regulation of mouse stomach motility were examined using mice genetically lacking muscarinic M(2) receptor and/or M(3) receptor and their corresponding wild-type (WT) mice. Single application of carbachol (1 nM-30 microM) produced concentration-dependent
Y Doi et al.
European journal of pharmacology, 505(1-3), 31-35 (2004-11-24)
This study characterized the functional effects of a novel gastroprokinetic agent, N-[2-(diisopropylamino)ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1, 3-thiazole-4-carboxyamide monohydrochloride trihydrate (Z338), on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes using the two-electrode voltage clamp method. Z-338 did not produce by itself
Leticia Ramírez-Lugo et al.
Neurobiology of learning and memory, 79(2), 184-193 (2003-02-20)
A number of studies have implicated cholinergic activity in the mediation of learning and memory processes. However, the specific role of muscarinic receptors in memory formation mechanisms is less known. The aim of the present study is to evaluate the
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