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Merck

SML0421

Sigma-Aldrich

SB265610

≥98% (HPLC)

别名:

1-(2-溴苯基)-3-(4-氰基-1H-苯并[d][1,2,3]三唑-7-基)脲, N-(2-溴苯基)-N′-(7-氰基-1H-苯并三唑-4-基)脲, SB 265610

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About This Item

经验公式(希尔记法):
C14H9BrN6O
分子量:
357.16
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to light brown

溶解度

DMSO: 15 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23

InChI

1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21)

InChI 密鑰

SEDUMQWZEOMXSO-UHFFFAOYSA-N

應用

SB265610已用于:
  • 作为一种半胱氨酸-氨基酸-半胱氨酸(CXC)-趋化因子受体2(CXCR2)拮抗剂,研究其对趋化因子与G蛋白偶联受体(GPCR)结合的影响
  • 作为一种CXC-趋化因子受体1(CXCR1)抑制剂,研究其对炎症细胞趋化因子趋化活性的影响
  • 作为一种CXCR2拮抗剂,研究其对中性粒细胞向大鼠脑内迁移的影响

生化/生理作用

SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。
SB265610是一种强效、选择性CXCR2趋化因子受体拮抗剂。 其Kd = 2.5 nM。

特點和優勢

《受体分类和信号转导》手册的 趋化因子受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

François Binet et al.
Science (New York, N.Y.), 369(6506) (2020-08-21)
In developed countries, the leading causes of blindness such as diabetic retinopathy are characterized by disorganized vasculature that can become fibrotic. Although many such pathological vessels often naturally regress and spare sight-threatening complications, the underlying mechanisms remain unknown. Here, we
Tao Zhang et al.
European journal of immunology, 48(6), 1059-1073 (2018-02-21)
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here, we found MDSCs significantly increased in the peripheral blood of patients with
Zongmin Jiang et al.
Scientific reports, 7(1), 14510-14510 (2017-11-08)
Microenvironment (or niche)-providing chemokines regulate many important biological functions of tissue-specific stem cells. However, to what extent chemokines influence human pluripotent stem cells (hPSCs) is not yet completely understood. In this study, we applied protein array to screen chemokines found
Jing Zhao et al.
Scientific reports, 7(1), 16128-16128 (2017-11-25)
The pulsatile nature of blood flow exposes vascular smooth muscle cells (VSMCs) in the vessel wall to cyclic mechanical stretch (CMS), which evokes VSMC proliferation, cell death, phenotypic switching, and migration, leading to vascular remodeling. These responses have been observed
Julia Esser-von Bieren et al.
PLoS pathogens, 11(3), e1004778-e1004778 (2015-03-26)
Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptive multicellular parasites might

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