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Merck

SML0152

Sigma-Aldrich

AK-7

≥98% (HPLC)

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About This Item

经验公式(希尔记法):
C19H21BrN2O3S
分子量:
437.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.25

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to tan

溶解度

DMSO: ≥15 mg/mL

儲存溫度

2-8°C

SMILES 字串

Brc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)c1

InChI

1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)

InChI 密鑰

IYAYHZZWYNXHEQ-UHFFFAOYSA-N

一般說明

AK-7 (3-(1-azepanylsulfonyl)-N-(3-bromphenyl) benzamide) is a cell- and brain-permeable, selective SIRT2 (sirtuin 2) inhibitor.

應用

AK-7 has been used in cell culture and cell treatment.

生化/生理作用

In neurons, the sirtuin 2 inhibitor AK-7 is neuroprotective in vitro and decreases polyglutamine inclusions and cholesterol levels. In mice, treatment with brain-permeable SIRT2 inhibitor AK-7 led to improved motor function, extended survival and decreased brain atrophy. AK-7 decreases the polyglutamine aggregation in R6/2 brain.
Selective SIRT2 Inhibitor AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
AK-7 is a brain penetrant selective SIRT2 inhibitor. No inhibition of SIRT1 or SIRT3 detected.
Selective SIRT2 Inhibitor

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
Motyl J, et al.
Molecular Neurobiology, 55(1), 727-740 (2018)
The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models
Chopra V, et al.
Cell Reports, 2(6), 1492-1497 (2012)
Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7
Wang X,et al.
Drug design, development and therapy (2015)
Matthew A Kunicki et al.
Journal of immunology (Baltimore, Md. : 1950), 200(1), 336-346 (2017-11-29)
Human CD3
Nagako Sougawa et al.
Transplantation, 103(5), e119-e127 (2019-02-08)
The extracellular matrix, in particular basement membrane components such as laminins (LMs), is essential for stem cell differentiation and self-renewal. LM511 and LM221 are the main extracellular matrix components of the epicardium, where stem cells were abundant. Here, we examined

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