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SML0007

Sigma-Aldrich

Cevimeline hydrochloride hemihydrate

≥95% (HPLC, NMR)

别名:

AF-102B, SNI-2011

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About This Item

经验公式（希尔记法）:
C10H17NOS · xHCl · yH2O
CAS号:
153504-70-2
分子量:
199.31 (anhydrous free base basis)
分類程式碼代碼:
12352200
PubChem物質ID:
329825084
NACRES:
NA.77

品質等級

100

化驗

≥95% (HPLC, NMR)

形狀

powder

儲存條件

desiccated

顏色

white to tan

溶解度

H2O: ≥25 mg/mL

起源

Daiichi-Sankyo

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6

InChI

1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1

InChI 密鑰

ZSTLCHCDLIUXJE-GMLJRNIPSA-N

應用

Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.

生化／生理作用

Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.
Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca+2 in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Kentaro Ono et al.
The journal of medical investigation : JMI, 56 Suppl, 375-375 (2009-01-01)
Previous reports suggested that there is no significant difference in the binding affinity of pilocarpine and cevimeline on muscarinic receptors (1). However, in vivo studies from our laboratory suggested that pilocarpine-induced salivation from the parotid gland is greater than that
Hirotaka Ueda et al.
The journal of medical investigation : JMI, 56 Suppl, 267-269 (2009-01-01)
Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it

商品

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

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