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SMB00445

Sigma-Aldrich

灵芝酸 A

≥98% (HPLC)

别名:

(2R,6R)-6-[(5R,7S,10S,13R,14R,15S,17R)-7,15-二羟基-4,4,10,13,14-五甲基-3,11-二氧-2,5,6,7,12,15,16,17-八氢-1H-环戊基a[a]菲烯-17-基]-2-甲基-4-氧庚酸, (7β,15α,25R);7,15-二羟基-3,11,23-三氧-8-烯-26-酸

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About This Item

经验公式（希尔记法）:
C30H44O7
CAS号:
81907-62-2
分子量:
516.67
分類程式碼代碼:
12352205
PubChem物質ID:
329825018
NACRES:
NA.25

品質等級

200

化驗

≥98% (HPLC)

形狀

powder

應用

metabolomics
vitamins, nutraceuticals, and natural products

儲存溫度

−20°C

SMILES 字串

OC(C(C)CC(C[C@@H](C)[C@H]1C[C@H](O)[C@@]([C@]1(C)CC2=O)(C)C3=C2[C@]4(C)C(C[C@@H]3O)C(C)(C)C(CC4)=O)=O)=O

InChI

1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21?,23+,28+,29-,30+/m1/s1

InChI 密鑰

DYOKDAQBNHPJFD-ZQEHRSJRSA-N

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相关类别

一般說明

灵芝酸A(Ganoderic Acid A)或GAA是灵芝(Ganoderma lucidum)真菌中最丰富的三萜类物质之一。GAA的化学结构中有四个环，在支链上有一个双键和一个末端羧基。

應用

灵芝酸A已用于：
  • 研究其对缺氧诱导大鼠心肌细胞(H9c2)损伤的保护作用
  • 作为参考标准品，研究其对豇豆植物中花生芽坏死病毒(GBNV)的抑制和抗病毒作用
  • 作为傅里叶变换红外(FT-IR)光谱技术的标准品，分析灵芝来源的次级代谢物

生化／生理作用

灵芝酸A(GAA)可改善高脂饲料(HFD)喂养小鼠的脂质代谢、肠道菌群组成和高脂血症。它在多项体外研究中被证明可作为抗癌药物，抑制乳腺癌、人肝细胞癌细胞和骨肉瘤的细胞增殖。灵芝酸A对脑卒中后抑郁(PSD)大鼠模型具有抗抑郁样行为、炎症和神经损伤的神经保护作用。还具有抗人免疫缺陷型病毒(HIV-1)活性。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
SLCM0007
SLCL2259
SLCJ8091
SLCB2649
SLBM6032V

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Xu Wang et al.
Molecular medicine reports, 16(4), 3894-3900 (2017-07-22)
Ganoderic acid A (GA‑A), a triterpenoid, has been demonstrated to suppress cell proliferation in various cancers, including breast cancer and osteosarcoma. However, its effect on human hepatocellular carcinoma (HCC) remains to be elucidated. The present study aimed to investigate the
Jiahua Jiang et al.
International journal of molecular medicine, 21(5), 577-584 (2008-04-22)
Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, GA-H), were identified in an oriental medicinal mushroom Ganoderma lucidum. In the present study we evaluated the effect of GA-A, GA-H and GA-F on highly invasive human breast
Yanhua Chang et al.
Phytotherapy research : PTR, 33(5), 1448-1456 (2019-03-07)
Effects of ganoderic acid A (GAA), a lanostane triterpene, on hypoxia-ischemia encephalopathy (HIE) remain unclear. We aimed to figure out the specific role of GAA in hypoxia-treated neural stem cells (NSCs) as well as the regulatory mechanisms. Primary rat NSCs
Xiaohong Zhang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(6), 2086-2096 (2018-11-12)
Ganoderic acid A (GAA) isolated from Ganoderma lucidum, shows various benefit activities, such as anti-tumor activity, anti-HIV activity and hepatoprotective activity. However, the potential effects of GAA on hypoxia-induced injury of cardiomyocytes are still unclear. In this study, we aimed
Chandan Saini et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 233, 84-88 (2019-04-12)
Humans have greatly altered Earth's night-time photic environment via the production of artificial light at night (ALAN; e.g. street lights, car traffic, billboards, lit buildings). ALAN is a problem of growing importance because it may significantly disrupt the seasonal and
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