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化驗
≥95% (LC/MS-ELSD)
形狀
solid
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
−20°C
SMILES 字串
CC1(C)CCC[C@@]2(C)C1CC(=O)c3cc(O)c(O)cc23
InChI
1S/C17H22O3/c1-16(2)5-4-6-17(3)11-8-14(20)13(19)7-10(11)12(18)9-15(16)17/h7-8,15,19-20H,4-6,9H2,1-3H3/t15?,17-/m1/s1
InChI 密鑰
JMBKXUYCBVKSSY-OMOCHNIRSA-N
一般說明
Natural product derived from plant source.
Nimbidiol is a modified diterpenoid. It is isolated from the root-bark of Azadirachta indica (Indian ‘neem′).
生化／生理作用
Nimbidiol has an ability to inhibit intestinal glucosidases, including maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and fungal α-glucosidases. Thus, this bioactive molecule has all the potential to be used as an anti-diabetic drug
訊號詞
Warning
危險聲明
防範說明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nimbidiol, a modified diterpenoid of the root-bark of Azadirachta indica
Majumder P L, et al.
Phytochemistry, 26(11), 3021-3023 (1987)
Abhishek Mukherjee et al.
Journal of enzyme inhibition and medicinal chemistry, 28(5), 900-910 (2012-07-19)
Azadirachta indica, used in antidiabetic herbal drugs, was reported to contain α-glucosidase inhibitor. Bioassay guided purification characterized the inhibitor as nimbidiol (a diterpenoid), present in root and stem-bark of the tree. Nimbidiol inhibited intestinal (mammalian) maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and
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