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化驗
≥95% (HPLC)
形狀
lyophilized
成份
Peptide Content, ≥80%
儲存條件
protect from light
溶解度
1 mg/mL at in water (Add acetonitrile dropwise to solution in water, mixing until the peptide dissolves)
儲存溫度
−20°C
Amino Acid Sequence
Suc-Asp-Glu-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
應用
IRL-1620 is used as a specific endothelin-B receptor (ET(B)-R) agonist.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
儲存類別代碼
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Manish S Lavhale et al.
Pharmacological research, 62(6), 489-499 (2010-09-10)
Clonidine decreases mean arterial pressure (MAP) by acting as an α(2)-adrenergic receptor (AR) agonist in the central nervous system; it also acts on peripheral α-ARs to produce vasoconstriction. Endothelin (ET) has been shown to modulate the action of ARs. The
Fernando S Carneiro et al.
The journal of sexual medicine, 5(12), 2793-2807 (2008-10-01)
The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation
A Gulati et al.
Arzneimittel-Forschung, 62(1), 14-17 (2012-02-15)
ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor
Mary G Leonard et al.
Brain research, 1420, 48-58 (2011-10-01)
Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies indicate that ET(B) receptors may provide both vasodilatation and neuroprotection. The purpose of this study was to determine the effect of selectively
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