SAB5702470

Anti-TRPM8 Antibody, clone 9S8N1, Rabbit Monoclonal

• 别名: LTRPC6, TRPP8
• 分類程式碼代碼: 12352203
• NACRES: NA.46

属性

• 生物源: rabbit
• 品質等級: 100
• 材料: colorless
• 無性繁殖: 9S8N1, monoclonal
• 形狀: liquid
• 分子量: 110 kDa
• 物種活性: human
• 濃度: 0.77 mg/mL
• 技術: western blot: 1:500 - 1:2000
• 顏色: colorless
• 同型: IgG
• 免疫原序列: FRSVIYEPYLAMFGQVPSDVDGTTYDFAHCTFTGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYF
• UniProt登錄號: Q7Z2W7
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... TRPM8(79054)

说明

一般說明

Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 900-1000 of human TRPM8 (Q7Z2W7).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

應用

WB

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1