推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
1F5, monoclonal
形狀
buffered aqueous solution
物種活性
human
技術
indirect ELISA: suitable
western blot: 1-5 μg/mL
同型
IgG1κ
GenBank登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TRPV1(7442)
一般說明
基因编码瞬时受体电位阳离子通道,亚族V,成员1(TRPV1)定位到人类染色体17p13。它是非选择性阳离子通道。该蛋白在气道神经纤维上表达。它也在感觉神经元中强烈表达。
免疫原
TRPV1(NP_542437, 21 a.a.~ 124 a.a)带有GST标签的部分重组蛋白。仅GST标签的MW为26 KDa。
序列
CPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQ
序列
CPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQ
生化/生理作用
瞬时受体电位阳离子通道亚家族V成员1(TRPV1)是辣椒素受体。它参与疼痛感知。TRPV1还调节传入信号和支气管收缩。在大脑中,它调节神经元功能、运动行为和神经炎症。辣椒素在TRPV1的激活中起着重要作用。
外觀
溶于pH7.4的磷酸盐缓冲盐水中的溶液
法律資訊
GenBank is a registered trademark of United States Department of Health and Human Services
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
The 57 kb deletion in cystinosis patients extends into TRPV1 causing dysregulation of transcription in peripheral blood mononuclear cells.
Journal of medical Genetics (2011)
Role of transient receptor potential vanilloid 1 in the modulation of airway smooth muscle tone and calcium handling.
American Journal of Physiology. Lung Cellular and Molecular Physiology (2017)
TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson's disease via CNTF.
Brain (2015)
Cardiovascular research, 103(4), 607-618 (2014-06-18)
The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression. However, recent reports indicate that high doses of
Neuropharmacology, 85, 142-150 (2014-05-28)
Painful diabetic neuropathy is a disease of the peripheral sensory neuron with impaired opioid responsiveness. Since μ-opioid receptor (MOR) activation can inhibit the transient receptor potential vanilloid 1 (TRPV1) activity in peripherally sensory neurons, this study investigated the mechanisms of
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