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生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
1696, monoclonal
形狀
buffered aqueous solution
物種活性
human immunodeficiency virus
濃度
1 mg/mL
技術
FUNC: suitable
immunoblotting: suitable
indirect ELISA: suitable
同型
IgG1
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
一般說明
Human immunodeficiency virus (HIV) protease expressed in the 5′ end of pol gene is part of gag-pol polyprotein. HIV protease has 99 amino acids. The monomers of the protein are inactive; homodimers of the protein are enzymatically active. The antibody 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. The antibody 1696 does not react with the precursor.
免疫原
Bacterially expressed full-length HIV-1 protease
生化/生理作用
HIV protease is an aspartyl protease which is essential for cleavage of viral progenitor polyprotein. Protease activity is critically essential for the life cycle of the virus. HIV protease cleaves gag protein into three larger fragments p24, p17 and p7, which are the core structural protein and essential for RNA packaging. Protease also cleaves gag-pol fusion protein of the virion. The favourable cleavage site of HIV protease is N-terminal to proline, like phenylalanine-proline, tyrosine-proline, which is uncommon for mammalian proteases. The cleavage happens after the budding of the virion from the infected cell surface, transform into a mature infectious virus. Lack of protease results in immature and non-infectious viral particles. Inhibitors targeted to HIV protease is the recent advancement in the treatment of HIV infection.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
HIV-protease inhibitors
The New England Journal of Medicine, 338(18), 1281-1293 (1998)
The mechanism of insulin resistance caused by HIV protease inhibitor therapy
The Journal of Biological Chemistry, 275(27), 20251-20254 (2000)
HIV protease: a novel chemotherapeutic target for AIDS
Journal of Medicinal Chemistry, 34(8), 2305-2314 (1991)
Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme
Journal of the American Chemical Society, 117(3), 1181-1182 (1995)
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