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Merck
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Key Documents

SAB4700113

Sigma-Aldrich

Monoclonal Anti-CD19-PE antibody produced in mouse

clone LT19, purified immunoglobulin, buffered aqueous solution

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.44

生物源

mouse

共軛

phycoerythrin (R-PE) conjugate

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

LT19, monoclonal

形狀

buffered aqueous solution

物種活性

human

技術

flow cytometry: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

human ... CD19(930)

一般說明

CD19 (cluster of differentiation 19) is a 95kDa protein localized on the surface of nearly all B lymphocytes and is considered to be the specific surface marker for B cells.This protein belongs to the immunoglobulin (Ig) superfamily with a cytoplasmic region of 240 amino acids and is involved in the regulation of B cell function.The protein is encoded by the 7.41kb cd19 gene, mapped on the short arm of human chromosome 16p11.2. There are certain localized regions of strong net negative charges with nine tyrosine residues in the cytoplasmic region of CD19. These regions might regulate the interaction of CD19 with the proto-oncogene Vav, phosphatidylinositol-3 kinase (PI-3 kinase) and the Lyn, Lck and Fyn protein tyrosine kinases.

免疫原

Daudi human Burkitt lymphoma cell line

應用

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

生化/生理作用

CD19 (cluster of differentiation 19) expression is restricted to normal and malignant B-lineage cells. Therefore, it is considered to be a striking target for immunotherapies aimed at B-cell malignancies. CD19 helps B lymphocytes to initiate primary immune response even at low concentrations of antigen.The encoded protein plays a crucial role in initiating intrinsic B cell signaling thresholds by regulating both B cell receptor (BCR)-dependent and independent signaling. It also functions as a biomarker for B-cell development.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity.
Fearon DT and Carter RH.
Annual Review of Immunology, 127-149 (1995)
CD19: a biomarker for B cell development, lymphoma diagnosis and therapy.
Wang K
Experimental Hematology & Oncology, 1 (2012)
The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.
Bradbury LE
Journal of Immunology, 149, 2841-2850 (1992)
CD19 monoclonal antibody HD37 inhibits anti-immunoglobulin-induced B cell activation and proliferation.
Pezzutto A
Journal of Immunology, 138, 2793-2799 (1987)
The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity.
Tedder TF
Immunity, 6, 107-118 (1997)

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