推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
LT95, monoclonal
形狀
buffered aqueous solution
物種活性
human
濃度
1 mg/mL
技術
flow cytometry: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... FAS(355)
一般說明
CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.
免疫原
HUT-78 human T cell lymphoma cell line
應用
Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.
生化／生理作用
CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Downregulation of Fas Gene Expression in Sezary Syndrome Is Associated with Promoter Hypermethylation
Jones CL
The Journal of Investigative Dermatology, 130, 1116-1125 (2010)
Chlorpyrifos and Cypermethrin Induce Apoptosis in Human Neuroblastoma Cell Line SH-SY5Y
Raszewski G
Basic and Clinical Pharmacology and Toxicology, 116, 158-167 (2015)
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
Kischkel FC
The Embo Journal, 14, 5579-5588 (1995)
Exploring prostate cancer genome reveals simultaneous losses of PTEN, FAS and PAPSS2 in patients with PSA recurrence after radical prostatectomy.
Ibeawuchi C
International Journal of Molecular Sciences, 16, 3856-3869 (2015)
Katrin A Salva et al.
Photochemistry and photobiology, 94(5), 1058-1065 (2018-04-21)
Aminolevulinate-based photodynamic therapy (ALA-PDT) selectively eliminates diseased tissues primarily through the induction of intrinsic apoptotic pathway. ALA-PDT is a first-line therapy for actinic keratosis, however, it is less effective for cutaneous T-cell lymphoma (CTCL). We have previously demonstrated that the
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