SAB4504467

Anti-phospho-MEK1/2 (pSer²²¹) antibody produced in rabbit

affinity isolated antibody

• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 43 kDa
• 物種活性: rat, mouse, human
• 濃度: ~1 mg/mL
• 技術: ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI登錄號: P36507; Q02750
• UniProt登錄號: P36507
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 目標翻譯後修改: phosphorylation (pSer221)
• 基因資訊: human ... MAP2K1(5604) , MAP2K2(5605)

说明

免疫原

The antiserum was produced against synthesized peptide derived from human MEK1/2 around the phosphorylation site of Ser221.

Immunogen Range: 193-242

生化／生理作用

MAP2k1/2 (dual specificity mitogen-activated protein kinase kinase 1/2) is a serine threonine kinase and is required for ERK (extracellular-signal-regulated kinase) activation. Activation of ERK is associated with production of IL-10 (interleukin 10) and IL-12. Absence of the Map2k1 gene results in embryonic lethality. Map2k1 is responsible for the stimulation of epidermal proliferation, regulating cell migration in fibroblasts. Deficiency of Map2k1 protein causes lupus-like syndrome. The gene encoding Map2k1 is localized on human chromosome 15q22.31 and the MAP2K2 gene is localized on human chromosome 19p13.3.

特點和優勢

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外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable