推荐产品
产品名称
抗-黏着斑蛋白 兔抗, affinity isolated antibody
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 123 kDa
物種活性
mouse, human, rat
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... VINC(7414)
一般說明
黏着斑蛋白（VCL）是一种广泛表达的细胞骨架蛋白，由定位于人类染色体10q11.2-qter 上的基因编码。VCL是粘附型细胞连接的重要成分。黏着斑蛋白结构包含一个球形头部，其通过富含脯氨酸的短序列连接到尾部结构域，头部与尾部之间的分子内相互作用掩盖了蛋白质中的各种配体结合位点。
免疫原
针对人源粘着斑蛋白的合成肽产生抗血清。
免疫原范围：786-835
免疫原范围：786-835
生化／生理作用
黏着斑蛋白（VCL）是一种细胞骨架蛋白，可支持细胞与细胞和细胞与基质连接。它可控制粘附和运动以及细胞伸展，因此也基本参与了正常的胚胎发育和心脏功能。在成熟的黏着斑（FA）中，VCL是“分子离合器”的重要组成部分，“分子离合器”可将力从细胞质F-肌动蛋白传递至膜结合整合素。VCL的畸变或突变会导致心肌病，这与高血压有关。实验研究表明，VCL可作为衰老或心力衰竭的生物标志物。黏着斑蛋白与FA相关，参与多种细胞功能，如稳定和增强FA，促进其成熟、细胞外基质（ECM）机械敏感化，调节肌动蛋白的细胞骨架动力学和参与凋亡的信号转导途径。
特點和優勢
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
外觀
兔IgG，溶于磷酸盐缓冲盐水（不含Mg2+和Ca2+），pH 7.4，含150mM NaCl、0.02％叠氮化钠和50％甘油。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Wolfgang H Ziegler et al.
Trends in cell biology, 16(9), 453-460 (2006-08-09)
Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for both cell-cell and cell-extracellular matrix (focal adhesion) adherens-type junctions, but its function has remained elusive. Vinculin is made up of a globular head linked to a tail
Qin Yu et al.
Scientific reports, 5, 15245-15245 (2015-10-22)
Hypertension is the most common and lethal risk factor for cardiovascular disease (CVD). Numerous variants have been associated with hypertension, however, most of which failed to get replication due to ethnic differences. In this study, we analyzed associations of 10
Tina Izard et al.
The Journal of biological chemistry, 291(6), 2548-2555 (2016-01-06)
The cytoskeletal protein vinculin is a major regulator of cell adhesion and attaches to the cell surface by binding to specific phospholipids. Structural, biochemical, and biological studies provided much insight into how vinculin binds to membranes, what components it recognizes
Lindsay B Case et al.
Nature cell biology, 17(7), 880-892 (2015-06-09)
Focal adhesions (FAs) link the extracellular matrix to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signalling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within FAs regulates their activity and function. Vinculin binds
Darrell R Borger et al.
Biochemical and biophysical research communications, 370(2), 230-234 (2008-03-25)
This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门