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Merck
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Key Documents

SAB4502511

Sigma-Aldrich

Anti-HECW2 antibody produced in rabbit

affinity isolated antibody

别名:

C2 and WW domain-containing protein 2, E3 ubiquitin-protein ligase HECW2, HECT, NEDD4-like E3 ubiquitin-protein ligase 2

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen 175 kDa

物種活性

human

濃度

~1 mg/mL

技術

ELISA: 1:5000
western blot: 1:500-1:1000

NCBI登錄號

Q9P2P5

UniProt登錄號

Q9P2P5

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... HECW2(57520)

一般說明

Anti-HECW2 Antibody detects endogenous levels of total HECW2 protein.

免疫原

The antiserum was produced against synthesized peptide derived from human HECW2.

Immunogen Range: 481-530

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

nwg

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Vidhya Krishnamoorthy et al.
Biochimica et biophysica acta. Molecular cell research, 1865(8), 1088-1104 (2018-05-14)
Lamins constitute the major architectural proteins of the nuclear lamina that help in maintaining nuclear organization. Mutations in lamins are associated with diverse degenerative diseases, collectively termed laminopathies. HECW2, a HECT-type E3 ubiquitin ligase, is transcriptionally upregulated in HeLa cells
Richa Khanna et al.
The FEBS journal, 285(12), 2243-2262 (2018-04-21)
Lamins are key nuclear proteins which are important for maintaining nuclear structure and function. Mutations in lamins cause a spectrum of genetic diseases termed as laminopathies. RING finger containing E3 ubiquitin ligase, RNF123, is transcriptionally upregulated in cells expressing rod

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