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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 87 kDa
物種活性
human, mouse, rat
濃度
~1 mg/mL
技術
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... FAP(2191)
一般說明
成纤维细胞活化蛋白1（FAP-1）是一种膜相关蛋白酪氨酸磷酸酶。它由ezrin样细胞骨架结合结构域，六个PSD95/Dlg/Z-1同源（PDZ）结构域和亮氨酸拉链基序组成。FAP-1基因位于人染色体4q21.3。抗-FAP-1抗体检测内源性总FAP-1蛋白水平。
免疫原
该抗血清是针对衍生自人FAP-1的合成肽而生成的。
免疫原范围： 331-380
免疫原范围： 331-380
應用
兔抗FAP-1抗体可用于蛋白质印迹分析（1：500）和免疫组织化学（10 μg/ml）。
生化／生理作用
成纤维细胞活化蛋白1（FAP-1）参与肿瘤发生，细胞凋亡，癌症进展和胰岛素信号传导。它可作为高级别浆液性卵巢癌和乳腺癌的预后标志物。FAP-1基因的过表达与几种人类癌症有关，例如肝细胞癌，胰腺癌，卵巢癌，血液学和结肠癌。FAP-1基因的突变会导致肝癌和肺癌。
特點和優勢
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
外觀
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Vladimir N Ivanov et al.
Molecular and cellular biology, 23(10), 3623-3635 (2003-05-02)
As revealed by intracellular pools of nonactive Fas (Apo-1), export of Fas to the cell surface is often impaired in human tumors, thereby inactivating Fas ligand-mediated apoptosis. Here, we demonstrate that association with Fas-associated phosphatase 1 (FAP-1) attenuates Fas export
Upregulation of miR-200c-3p induced by NaF promotes endothelial apoptosis by activating Fas pathway.
Yuting Jiang et al.
Environmental pollution (Barking, Essex : 1987), 266(Pt 1), 115089-115089 (2020-07-07)
Fluoride has been considered as a risk factor of cardiovascular disease due to its endothelial toxicology. However, the mechanism underlying the endothelial toxicity of fluoride has not been clearly illustrated. MiR-200c-3p was strongly linked with endothelial function and its level
Mohamed Hamyeh et al.
Theranostics, 10(3), 1016-1032 (2020-01-16)
Clinical data suggest that the protein tyrosine phosphatase PTPN13 exerts an anti-oncogenic effect. Its exact role in tumorigenesis remains, however, unclear due to its negative impact on FAS receptor-induced apoptosis. Methods: We crossed transgenic mice deleted for PTPN13 phosphatase activity
Sang-Ok Lee et al.
Biochemical and biophysical research communications, 478(3), 1205-1210 (2016-08-22)
Protein tyrosine phosphatase-Basophil (PTP-Bas) is a membrane-associated protein tyrosine phosphatase with five PDZ domains and is involved in apoptosis, tumorigenesis, and insulin signaling. The interaction between PTP-Bas and tandem-PH-domain-containing protein 1/2 (TAPP1/2) plays an essential role in the regulation of
J Inazawa et al.
Genomics, 31(2), 240-242 (1996-01-15)
PTPN13 is a protein tyrosine phosphatase that associates with the C-terminal negative regulatory domain in the Fas (APO-1/CD95) receptor. The PTPN13 protein contains six GLGF repeats that have been found in the rat postsynaptic density protein (PSD-95) and the Drosophila
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