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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 42 kDa
物種活性
human
濃度
~1 mg/mL
技術
ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCR7(1236)
一般說明
C-C motif chemokine receptor 7 (CCR7) also known as EBI1, is encoded by the gene mapped to human chromosome 17q12-q21.2. The encoded protein is a member of chemokine receptor family and is expressed mainly by B cells, T cells, and on activated mature dendritic cells (DCs).
CCR7 is a G protein-coupled seven-transmembrane domain receptor. It has two high-affinity ligands, secondary lymphoid chemokine (SLC) and EB11-ligand chemokine (ELC).
免疫原
The antiserum was produced against synthesized peptide derived from human CCR7.
Immunogen Range: 170-219
Immunogen Range: 170-219
應用
Anti-CCR7 antibody produced in rabbit has been used for proximity ligation assay (PLA).
Anti-CCR7 antibody produced in rabbit has been used in immunofluorescence (1:50).
生化／生理作用
C-C motif chemokine receptor 7 (CCR7) harmonizes the antigen-specific immune response by combining T cells, B cells, and dendritic cells (DCs), to form functional microenvironments in the secondary lymphoid organs. CCR7 controls trafficking of skin DC under both inflammatory and steady-state conditions. This protein is also involved in emigration pathway of mature DCs from the skin to regional lymph nodes in vivo. CCR7 oligomers function acts as a scaffolds to link distinct signaling pathways for cell migration. Interaction of CCR7 with its ligand, CCL21/6ckine is essential for preferential lymph node metastasis of gastric carcinoma.
CCR7 can stimulate the development of hepatocellular carcinoma (HCC). In human malignancies, CCR7 may act as an initiator of epithelial-mesenchymal transition (EMT).
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions.
Ohl L, et al.
Immunity, 21(2), 279-288 (2004)
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.
Forster R, et al.
Cell, 99(1), 23-33 (1999)
Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.
Hauser MA, et al.
Immunity, 44(1), 59-72 (2016)
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.
Lamy PJ, et al.
Breast Cancer Research, 13(1) (2011)
Lingling Yang et al.
Experimental cell research, 371(1), 231-237 (2018-08-15)
The effects of Histone deacetylase (HDAC) inhibition on epithelial-mesenchymal transition (EMT) differs in various types of cancers. However, its function in hepatocellular carcinoma (HCC) is not well-explored. In this study, we investigated the effect of HDAC inhibition on EMT in
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