推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~43 kDa
物種活性
human
濃度
1 mg/mL
技術
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(T-D-D-Y-I)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCR7(1236)
一般說明
Anti-CCR7 antibody detects endogenous level of total CCR7(CD197) protein. CCR7 (C-C motif chemokine receptor 7) is localized to T cells, natural killer and dendritic cells. The CCR7 gene is mapped to human chromosome 17q21.2.
免疫原
Peptide sequence around aa. 29-33 (T-D-D-Y-I), according to the protein NP_001829.1
生化／生理作用
CCR7 (C-C motif chemokine receptor 7) regulates lymphocyte cell trafficking and lymph node distribution. CCR7′s interaction with CCL21 promotes metastasis of cancer via lymph node. CCR7 is known to be associated with breast cancer, melanoma, colorectal cancer, non-small cell lung cancer, and chronic lymphocytic leukemia.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Confirmation of novel type 1 diabetes risk loci in families.
Cooper J D, et al.
Diabetologia, 55(4), 996-1000 (2012)
Association of CXCR4, CCR7, VEGF-C and VEGF-D expression with lymph node metastasis in patients with cervical cancer.
Dai Y, et al.
Eur. J. Obstet. Gyn. Rep. Biol., 214, 178-183 (2017)
Tumor hypoxia modulates podoplanin/CCL21 interactions in CCR7+ NK cell recruitment and CCR7+ tumor cell mobilization.
Tejchman A, et al.
Oncotarget, 8(19), 31876-31876 (2017)
Yang Qin et al.
BMC musculoskeletal disorders, 15, 316-316 (2014-09-28)
It is well-documented that both chemokine (C-C motif) ligand 19 (CCL19) and 21 (CCL21) mediate cell migration and angiogenesis in many diseases. However, these ligands' precise pathological role in ankylosing spondylitis (AS) has not been elucidated. The objective of this
José Peña et al.
AIDS research and human retroviruses, 30(6), 535-541 (2013-11-05)
Mechanisms leading to the observed immune dysregulation in chronic HIV infection are not well understood. The MHC-II class ligand, lymphocyte activation gene-3 (LAG-3, CD223), has been implicated in the complex regulation mechanism of immune functions. In this study, we describe
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