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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~93 kDa
物種活性
rat, mouse, human
濃度
1 mg/mL
技術
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(R-E-E-I-E)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Postn(50706)
一般說明
Periostin (POSTN) gene with 23 exons spanning 36 kb is mapped to chromosome 13q13.3. The gene codes for periostin, a matricellular protein that belongs to the family of non-structural matrix proteins. Periostin structure contains a signal peptide, four fasciclin-like domains (FAS1) with vitamin K-dependent γ-carboxyglutamic acid (Gla) residues, and hydrophilic C-terminal region with the heparin-binding site. The protein is mainly expressed in the periosteum, periodontal ligament, heart valves, and tendons. The antibody detects endogenous level of total periostin protein.
免疫原
Peptide sequence around aa. 125-129 ( R-E-E-I-E), according to the protein NP_006466.2
應用
Anti-POSTN antibody produced in rabbit has been used in western blot.
生化／生理作用
Periostin (POSTN) facilitates extracellular matrix structure and organization. It acts as a collagen chaperone and regulates type I collagen fibrillogenesis. POSTN is implicated in early stages of bone formation, tissue repair, and cell recruitment and adhesion. This protein is essential for cancer stem cell maintenance and metastasis. Increased expression of POSTN has been observed in various types of cancers including prostate, breast, lung, pancreatic, ovarian, and colorectal cancer. Hence, the postn levels can be used as a prognostic biomarker for these cancers.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
標靶描述
Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.
外觀
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Nicolas Bonnet et al.
The Journal of biological chemistry, 284(51), 35939-35950 (2009-10-20)
Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment and adhesion and plays an important role in odontogenesis. In bone, periostin is preferentially expressed in the periosteum, but its functional significance remains unclear. We investigated Postn(-/-)
Periostin Mediates Oestrogen-Induced Osteogenic Differentiation of Bone Marrow Stromal Cells in Ovariectomised Rats.
Li, et al.
BioMed Research International, 2020, 9405909-9405909 (2020)
Ilaria Malanchi et al.
Nature, 481(7379), 85-89 (2011-12-14)
Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successful initiation
Mukundan Attur et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(10), 4107-4121 (2015-06-21)
We investigated the role of periostin, an extracellular matrix protein, in the pathophysiology of osteoarthritis (OA). In OA, dysregulated gene expression and phenotypic changes in articular chondrocytes culminate in progressive loss of cartilage from the joint surface. The molecular mechanisms
Yan Lu et al.
The Journal of clinical investigation, 124(8), 3501-3513 (2014-07-09)
Hepatosteatosis is characterized by an aberrant accumulation of triglycerides in the liver; however, the factors that drive obesity-induced fatty liver remain largely unknown. Here, we demonstrated that the secreted cell adhesion protein periostin is markedly upregulated in livers of obese
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