HPA014488
抗-CCR6 兔抗
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-C-C CKR-6, Anti-C-C chemokine receptor type 6, Anti-CC-CKR-6, Anti-CCR-6, Anti-CD196 antigen, Anti-CKR-L3, Anti-Chemokine receptor-like 3, Anti-DRY6, Anti-G-protein coupled receptor 29, Anti-GPR-CY4, Anti-GPRCY4, Anti-LARC receptor
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About This Item
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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunohistochemistry: 1:50- 1:200
免疫原序列
KYNTQGSDVCEPKYQTVSEPIRWKLLML
UniProt登錄號
應用
research pathology
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCR6(1235)
一般說明
The gene CCR6 (C-C motif chemokine receptor 6) encodes a chemokine receptor that is mainly expressed in B cells and memory T cells. It is also found to be expressed in dendritic cells, spleen, thymus, small intestine, and peripheral blood leukocytes. The gene is mapped to human chromosome 6q27. It shares sequence similarity with G protein-coupled chemokine receptor. The acidic amino terminal contains two potential N-linked glycosylation sites, and two additional ones are located in the first and the third extracellular loops.
免疫原
C-C chemokine receptor type 6 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
The gene CCR6 (C-C motif chemokine receptor 6) encodes a chemokine receptor for the chemokine ligand CCL20, also referred to as LARC (liver and activation-regulated chemokine) or MIP-3 α (macrophage inflammatory protein-3 α). The binding of the ligand to the receptor facilitates the chemoattraction of immature dendritic cells, effector/memory T-cells and B-cells. It participates in pathology, including cancer and rheumatoid arthritis. In mucosal tissue, CCR6 participates in the regulation of humoral immunity and lymphocyte homeostasis. It also mediates dendritic cell localization.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST72741
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Pirus Ghadjar et al.
International journal of cancer, 125(4), 741-745 (2009-05-30)
Chemokines are a superfamily of small chemotactic cytokines, which interact with their G-protein-coupled receptors. These interactions regulate multiple physiological functions, particularly tissue architecture and compartment-specific migration of white blood cells. It has been found that the chemokine/chemokine receptor system has
Malte A Kluger et al.
Journal of the American Society of Nephrology : JASN, 25(6), 1291-1302 (2014-02-11)
A pathogenic role for Th17 cells in inflammatory renal disease is well established. The mechanisms underlying their counter-regulation are, however, largely unknown. Recently, Th17 lineage-specific regulatory T cells (Treg17) that depend on activation of the transcription factor Stat3 were identified.
F Liao et al.
Journal of immunology (Baltimore, Md. : 1950), 162(1), 186-194 (1999-01-14)
CC-chemokine receptor (CCR) 6 is the only known receptor for macrophage inflammatory protein (MIP)-3alpha, a CC chemokine chemotactic for lymphocytes and dendritic cells. Using anti-serum that we raised against the N-terminal residues of CCR6, we have characterized the surface expression
Tomohide Yamazaki et al.
Journal of immunology (Baltimore, Md. : 1950), 181(12), 8391-8401 (2008-12-04)
Th17 and regulatory T (Treg) cells play opposite roles in autoimmune diseases. However, the mechanisms underlying their proper migration to inflammatory tissues are unclear. In this study, we report that these two T cell subsets both express CCR6. CCR6 expression
Evemie Schutyser et al.
Cytokine & growth factor reviews, 14(5), 409-426 (2003-09-02)
CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins. The ligand-receptor pair CCL20-CCR6 is responsible
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