推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
LC3B-6, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~18/16 kDa
物種活性
human
濃度
~1.0 mg/mL
技術
immunoprecipitation (IP): 10-20 μg using lysates of human U-87 cells.
western blot: 1-2 μg/mL using whole extracts of HEK-293T cells over-expressing human LC3B.
同型
IgG2b
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAP1LC3B(81631)
一般說明
MAP1LC3B基因（微管相关蛋白1轻链3β）是酵母中的自噬相关基因ATG8的一种同源基因。编码的蛋白质称为pro-MAP1LC3B，这是一种被ATG4裂解以产生MAP1LC3B-1胞浆形式的前体形式。 小鼠单克隆抗LC3B抗体（小鼠IgG2b同种型）来源于LC3B-6杂交瘤，该杂交瘤是由小鼠骨髓瘤细胞与用对应于人LC3B N末端区域的合成肽免疫的BALB / c小鼠脾细胞融合产生。
免疫原
对应于人LC3B的N-末端区域的合成肽，与KLH耦合。相应的序列在大鼠和小鼠中相差一个氨基酸。
生化／生理作用
在自噬过程中被插入至生长中的自噬囊泡的内膜和外膜前，MAP1LC3B-I（微管相关蛋白1轻链3β-I）会结合MAP1LC3B-II。MAP1LC3B的细胞分布和加工有助于对自噬进行监测。缺乏MAP1LC3B的细胞被发现在自噬囊泡的形成中存在缺陷，其改变的表型与自噬在能量稳态和蛋白聚集体去除中的作用相关。它可作为一种自噬的标志物。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Autophagic degradation of the inhibitory p53 isoform Delta133p53alpha as a regulatory mechanism for p53-mediated senescence
Horikawa I, et al.
Nature Communications, 5 (2014)
Xing Feng et al.
Autophagy, 1-20 (2020-03-19)
Although the treatment of brain tumors by targeting kinase-regulated macroautophagy/autophagy, is under investigation, the precise mechanism underlying autophagy initiation and its significance in glioblastoma (GBM) remains to be defined. Here, we report that PAK1 (p21 [RAC1] activated kinase 1) is
Jean-Baptiste Gorin et al.
Frontiers in medicine, 2, 74-74 (2015-11-06)
Radiation emitted by the radionuclides in radioimmunotherapy (RIT) approaches induce direct killing of the targeted cells as well as indirect killing through the bystander effect. Our research group is dedicated to the development of α-RIT, i.e., RIT using α-particles especially
Shakeel U R Mir et al.
The Journal of biological chemistry, 290(10), 6071-6085 (2014-12-31)
Autophagy, a cellular recycling process responsible for turnover of cytoplasmic contents, is critical for maintenance of health. Defects in this process have been linked to diabetes. Diabetes-associated glucotoxicity/lipotoxicity contribute to impaired β-cell function and have been implicated as contributing factors
Shu Zhang et al.
Cell death & disease, 8(2), e2586-e2586 (2017-02-06)
EVA1A (Eva-1 homologue A) is a novel lysosome and endoplasmic reticulum-associated protein that can regulate cell autophagy and apoptosis. Eva1a is expressed in the myocardium, but its function in myocytes has not yet been investigated. Therefore, we generated inducible, cardiomyocyte-specific
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门