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Merck

SAB4200067

Sigma-Aldrich

Anti-PSPC1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-PSP1, Anti-Paraspeckle protein 1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

antigen ~45 kDa
antigen ~59 kDa

物種活性

human

濃度

~1.0 mg/mL

技術

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells
indirect immunofluorescence: 1.25-2.5 μg/mL using paraformaldehyde fixed HEK-293T cells
western blot: 0.5-1 μg/mL using lysates of HEK-293T cells

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... PSPC1(55269)
mouse ... Pspc1(66645)
rat ... Pspc1(305910)

一般說明

PSPC1 has two isoforms α and β.
Paraspeckle component 1 (PSPC1) is encoded by the gene mapped to human chromosome 13q12.11. The encoded protein is a member of DBHS (Drosophila Behavior Human Splicing) family of proteins.

應用

Anti-PSPC1 (C-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • ribonucleoprotein immunoprecipitation assay
  • immunofluorescence
  • immunocytochemistry

生化/生理作用

Paraspeckle component 1 (PSPC1) is involved in the regulation of nuclear receptors such as the progesterone receptor and the thyroid receptor and in a wide range of processes such as splicing and RNA metabolism.
Since paraspeckle component 1 (PSPC1) has lower background nucleoplasmic signal in various cell types compared to other members of DBHS (drosophila behavior human splicing) family of proteins, it is frequently used as a marker for paraspeckles. The encoded protein plays a vital role in regulation of transcription. Deletion of the gene is associated with the hindered psychomotor development, muscle hypotonia, unilateral microphtalmia with ptosis, congenital eye malformation and facial dysmorphic features.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

AKAP3 synthesis is mediated by RNA binding proteins and PKA signaling during mouse spermiogenesis
Xu K, et al.
Biology of Reproduction, 90(6), 119-111 (2014)
Paraspeckles
Fox A H
Cold Spring Harbor Perspectives in Biology, 2 (2010)
The Hepatitis Delta Virus accumulation requires paraspeckle components and affects NEAT1 level and PSP1 localization
Beeharry Y, et al.
Scientific Reports, 8(1), 6031-6031 (2018)
PSF and p54nrb/NonO-multi-functional nuclear proteins
Shav-Tal Y and Zipori D
Febs Letters, 531(2), 109-114 (2002)
First-trimester euploid miscarriages analysed by array-CGH.
Viaggi CD
Journal of applied genetics, 54, 353-359 (2013)

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