推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
分子量
22 kDa
物種活性
rat, human, mouse
濃度
1 mg/mL
技術
ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TM4SF1(4071)
一般說明
Transmembrane 4 L6 family member 1 (TM4SF1) is a protein encoded by the TM4SF1 gene in humans. It is a cell surface antigen, which is highly expressed in lung, breast, colon and ovarian carcinomas. The TM4SF1 gene is localized on human chromosome 3q25.1.
免疫原
Antibody was raised against an 18 amino acid peptide near the amino terminus of human TM4SF1.
生化／生理作用
Transmembrane 4 L6 family member 1 (TM4SF1) has a novel function in androgen receptor (AR) signaling. Its mRNA expression is higher in prostate cancer tissues as compared to benign prostatic hyperplasia (BPH). It is found to contribute to prostate cancer cell metastasis. The TM4SF1 gene serves as a molecular organizer that interacts with membrane and cytoskeleton-associated proteins. It uniquely initiates the formation of nanopodia and facilitates cell polarization and migration. TM4SF1 also regulates tumor cell motility and invasiveness. It is abundant on the plasma membrane and on intracellular vesicles.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
聯結
The action of this antibody can be blocked using blocking peptide SBP3500723.
外觀
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
相關產品
儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
he tumour-associated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility
Journal of Cell Science (2008)
KARE Genomewide Association Study of Blood Pressure
Using Imputed SNPs
Using Imputed SNPs
Kyung-Won Hong
Genomics & informatics, 103-107 (2010)
TM4SF1: a tetraspanin-like protein necessary for nanopodia formation and endothelial cell migration
Andrew Zukauskas
Angiogenesis, 14 (2011)
TM4SF1, a novel primary androgen receptor target gene over-expressed in human prostate cancer and involved in cell migration
Prostate, 71 (2011)
Cloning and expression of the tumor-associated antigen L6
J S Marken
Proceedings of the National Academy of Sciences of the USA, 89 (1992)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门