SAB3500544

Anti-NOD3 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 别名: Anti-CLR16.2, Anti-NLRC3, Anti-Nucleotide-binding oligomerization domain containing 3
• 分類程式碼代碼: 12352203
• NACRES: NA.41
• 共軛: unconjugated
• application: ELISA (i); IF; WB
• 無性繁殖: polyclonal
• 物種活性: rat, mouse, human
• citations: 4
• 技術: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable

属性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 物種活性: rat, mouse, human
• 技術: immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• NCBI登錄號: EAW85351
• UniProt登錄號: Q7RTR2
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NLRC3(197358)

说明

一般說明

NLR family CARD domain containing 3 (NLRC3), also referred to as nucleotide-binding oligomerization domain containing 3 (NOD3), is encoded by the gene mapped to human chromosome 16p13.3. The encoded protein belongs to the NLR protein family and is abundantly expressed in purified T cells, B cells and natural killer (NK) cells, but also in thymus, uterus and kidney.

免疫原

NOD3 antibody was raised against an 18 amino acid peptide near the center of human NOD3.

生化／生理作用

NLR family CARD domain containing 3 (NLRC3) negatively regulates nuclear factor-κB (NF-κB) activity and innate immune signaling induced by the DNA sensor STING (stimulator of interferon gene). NLRC3 inhibits mammalian target of rapamycin (mTOR) pathways involved in providing protection against colorectal cancer. Thus, downregulated expression of the gene has been observed in colorectal cancer and Wegener′s granulomatosis patients.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

聯結

The action of this antibody can be blocked using blocking peptide SBP3500544.

外觀

Supplied in PBS with 0.02% sodium azide.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable