推荐产品
生物源
rabbit
品質等級
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
51896 Da
物種活性
mouse, human
技術
flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... BECN1(8678)
一般說明
Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.
應用
ANTI-BECLIN 1 antibody produced in rabbit has been used for Western blotting.
生化/生理作用
Beclin 1 (BECN1) or GT197 acts as an initiator of autophagy and is vital in the early stages of autophagosome formation. It has a role in various tumors and cancers. BECN1 is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking.
外觀
Supplied in PBS with 0.09% (W/V) sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點(°F)
Not applicable
閃點(°C)
Not applicable
其他客户在看
Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma.
Molecular Medicine Reports (2016)
Class III phosphoinositide 3-kinase?Beclin1 complex mediates the amino
acid-dependent regulation of autophagy in C2C12 myotubes
acid-dependent regulation of autophagy in C2C12 myotubes
BioChemistry: An Indian Journal (2003)
CISD2 promotes the proliferation of glioma cells via suppressing beclin-1-mediated autophagy and is targeted by microRNA-449a
Molecular Medicine Reports (2017)
The BECN1 N-terminal domain is intrinsically disordered.
Autophagy (2016)
Polyglutamine tracts regulate beclin 1-dependent autophagy.
Nature (2017)
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