推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
Ig fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
mouse, human
技術
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
western blot: 1:100-1:500
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SOST(50964)
一般說明
SOST (sclerostin) gene codes for the protein sclerostin which is predominantly secreted by the osteocytes. The encoded protein is predominantly expressed in human woven and lamellar bone and mineralizing chondrocytes.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
免疫原
SOST (NP_079513, 12-42)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SOST.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SOST.
應用
Anti-SOST (N-term) antibody produced in rabbit has been used in immunohistochemistry.
生化／生理作用
Sclerostin regulates bone remodeling in presence of mechanical stimulation. It has an inhibitory effect on the activation of osteoblasts by inducing phosphorylation and degradation of β-catenin. It downregulates bone formation and induces bone resorption. Mutation in this gene causes hyperostosis and leads to Van Buchem disease or sclerosteosis. Increased bone formation and enhanced healing of bone defects are observed upon selective deletion of the SOST gene in mice model. Sclerostin, a glycoprotein, is involved in vascular calcification. It might be associated with cardiovascular disorders.
外觀
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
M Kosacka et al.
Advances in experimental medicine and biology, 910, 15-21 (2016-01-29)
Sclerostin, a glycoprotein involved in vascular calcification, could play a role in cardiovascular disorders. Obstructive sleep apnea (OSA) is frequently associated with cardiovascular comorbidities. Thus, in this study we set out to assess the level of sclerostin in patients with
Yusuke Inagaki et al.
Histopathology, 69(3), 470-478 (2016-02-21)
To assess the immunophenotypic and mRNA expression of sclerostin in human skeletal tissues and in a wide range of benign and malignant bone tumours and tumour-like lesions. Sclerostin expression was evaluated by immunohistochemistry and quantitative polymerase chain reaction (PCR). In
Abdul Rashid Qureshi et al.
Kidney international, 88(6), 1356-1364 (2015-09-04)
Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone disorder. In order to validate its potential as a predictor of vascular calcification, we explored associations of circulating sclerostin with measures of calcification in 89 epigastric artery biopsies
Asiri R Wijenayaka et al.
The Journal of steroid biochemistry and molecular biology, 164, 369-373 (2015-12-23)
The osteocyte expressed gene SOST encodes sclerostin, a potent negative regulator of bone formation and inducer of bone resorption. We have recently demonstrated that the human SOST gene is positively regulated in response to 1α,25-dihydroxyvitamin D
Rui Shu et al.
PloS one, 12(1), e0167312-e0167312 (2017-01-13)
Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement. In this study, models
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