推荐产品
生物源
human
品質等級
重組細胞
expressed in HEK 293 cells
化驗
≥95% (SDS-GE)
形狀
lyophilized powder
分子量
32 kDa by SDS-PAGE (nonglycosylated form, under reducing conditions)
35 kDa by SDS-PAGE (glycosylated form, under reducing conditions)
技術
ligand binding assay: suitable
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... FASLG(356)
應用
ED50 = 1 ng/ml on A20 cells. Does not require any enhancer, as the modified linker sequence already facilitates the formation of active FasL complexes. rhsSuperFas Ligand™ recognizes its receptor Fas (CD95) of the following species: human, rat, mouse.
生化／生理作用
Fas ligand has also been shown to be involved in the activation of non-apoptotic pathways including proliferation and NF-κ B activation.
Fas ligand, a protein belonging to the tumor necrosis factor (TNF) family of cytokines, induces apoptosis in cells expressing the cell membrane receptor Fas (CD95/Apo-1).
法律資訊
SuperFas Ligand is a trademark of Alexis Biochemicals Corp.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Harald Wajant et al.
Cytokine & growth factor reviews, 14(1), 53-66 (2002-12-18)
Fas (Apo-1, CD95) and Fas-Ligand (FasL, CD95L) are typical members of the TNF receptor and TNF ligand family, respectively, with a pivotal role in the regulation of apoptotic processes, including activation-induced cell death, T-cell-induced cytotoxicity, immune privilege and tumor surveillance.
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