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S7826

Sigma-Aldrich

SMER3

≥98% (HPLC)

别名:

9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one

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About This Item

经验公式（希尔记法）:
C11H4N4O2
CAS号:
67200-34-4
分子量:
224.18
MDL號碼:
MFCD00451458
分類程式碼代碼:
12352200
PubChem物質ID:
329824591
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: ≥30 mg/mL

儲存溫度

2-8°C

SMILES 字串

O=C1c2ccccc2-c3nc4nonc4nc13

InChI

1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChI 密鑰

SFSSAKVWCKFRHE-UHFFFAOYSA-N

應用

SMER3 may be used in cell signaling studies.

生化／生理作用

Inhibition of SCFMet30 by SMER3 blocks the ubiquitination of Met4 and activates the Met4-containing transcription complex. The induction of MET-genes results in cell cycle arrest and reduced cell proliferation.1
Small molecule enhancer of rapamycin (SMER); specific inhibitor of Ubiquitin E3 ligase.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Mariam Aghajan et al.
Nature biotechnology, 28(7), 738-742 (2010-06-29)
The target of rapamycin (TOR) plays a central role in eukaryotic cell growth control. With prevalent hyperactivation of the mammalian TOR (mTOR) pathway in human cancers, strategies to enhance TOR pathway inhibition are needed. We used a yeast-based screen to

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Oncogenes and Tumor Suppressors Reprogram Metabolism

We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

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