所有图片(1)
About This Item
经验公式（希尔记法）:
C15H13N3S
CAS号:
分子量:
267.35
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
solid
溶解度
DMSO: soluble 26 mg/mL
H2O: insoluble
儲存溫度
room temp
SMILES 字串
Cc1cccc(Nc2nc(cs2)-c3ccncc3)c1
InChI
1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)
InChI 密鑰
KATNUHQNJGNLPW-UHFFFAOYSA-N
應用
STF-62247 may be used as positive control in autophagy inducing cell signaling studies.
生化／生理作用
STF-62247 induces the formation of large vacuoles in the von Hippel-Lindau deficient renal carcinoma cells, a characteristic of autophagy.1
STF-62247 is a selective inducer of autophagy in VHL-deficient renal cell carcinoma cells.
危險聲明
防範說明
危險分類
Aquatic Chronic 4
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Sandra Turcotte et al.
Autophagy, 4(7), 944-946 (2008-09-05)
Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC
Tomohiro Kozako et al.
BMC cancer, 18(1), 791-791 (2018-08-08)
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 expression increases in acute myeloid leukemia blasts. Downregulation of SIRT2 using siRNA causes apoptosis
Kanchan Phadwal et al.
Autophagy, 8(4), 677-689 (2012-02-04)
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical
Maximilian N Kinzler et al.
Scientific reports, 10(1), 687-687 (2020-01-22)
Induction of autophagy can have beneficial effects in several human diseases, e.g. cancer and neurodegenerative diseases (ND). Here, we therefore evaluated the potential of two novel autophagy-inducing compounds, i.e. STF-62247 and pimozide, to stimulate autophagy as well as autophagic cell
Nadia Bouhamdani et al.
American journal of physiology. Cell physiology, 316(5), C605-C620 (2019-02-14)
Autophagy is a highly conserved, homeostatic process by which cytosolic components reach lysosomes for degradation. The roles played by different autophagic processes in cancer are complex and remain cancer type and stage dependent. Renal cell carcinoma (RCC) is the most
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