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Merck
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主要文件

R4408

Sigma-Aldrich

氯霉素

Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), ≥98% (HPLC)

别名:

D-(-)-苏-2,2-二氯-N-[β-羟基-α−（羟甲基）-β-（4-硝基苯基）乙基]乙酰胺, D-(-)-苏-2-二氯乙酰胺基-1-（4-硝基苯基）-1,3-丙二醇, D-苏-2,2-二氯-N-[β-羟基-α-（羟甲基）-4-硝基苯乙基]乙酰胺

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About This Item

分類程式碼代碼:
51102831
NACRES:
NA.85

品質等級

200

化驗

≥98% (HPLC)

形狀

solution

濃度

100 mg/mL in ethanol: isopropanol (95:5)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

protein synthesis | interferes

運輸包裝

dry ice

儲存溫度

−20°C

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應用

氯霉素是一种合成抗生素，从委内瑞拉链霉菌菌株中分离出来。 它通常以10-20 μg/mL的浓度用于分子生物学应用中的细菌选择，并作为含有氯霉素抗性基因的转化细胞的选择剂。

生化／生理作用

作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。

耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。

抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。

包裝

10ml

準備報告

该产品是在乙醇：异丙醇（95:5）中制备的100 mg/mL溶液。 干冰运输，-20℃下保存。

其他說明

保存于密闭容器内，置于干燥通风处。打开的容器必须小心地重新密封，并保持直立以防止泄漏。储存等级（TRGS 510）：易燃液体“）

訊號詞

Danger

危險分類

Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

57.2 °F - closed cup

閃點（°C）

14.0 °C - closed cup

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
056M4061V
099M4138V
11190435
068M4094V
068M4049V

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