跳转至内容
Merck

R2029

Sigma-Aldrich

Monoclonal Anti-Rapsyn antibody produced in mouse

1 mg/mL, clone 1234, purified immunoglobulin, buffered aqueous solution

别名:

Anti-CMS11, Anti-CMS4C, Anti-FADS, Anti-FADS2, Anti-RAPSYN, Anti-RNF205

登录查看公司和协议定价


About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41
共軛:
unconjugated
application:
WB
無性繁殖:
1234, monoclonal
物種活性:
amphibian, chicken, mouse, rat, fish
citations:
8
技術:
western blot: 0.5 μg/mL using Torpedo californica electrocyte cell extracts

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

1234, monoclonal

形狀

buffered aqueous solution

物種活性

amphibian, chicken, mouse, rat, fish

濃度

1 mg/mL

技術

western blot: 0.5 μg/mL using Torpedo californica electrocyte cell extracts

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

mouse ... Rapsn(19400)
rat ... Rapsn(362161)

一般說明

The receptor-associated protein of the synapse (RAPSYN) is a peripheral membrane protein located in the skeletal muscles. It is co-localized along with nicotinic acetylcholine receptors (nAChRs) at the postsynaptic membrane due to the influence of neural agrin. Rapsyn consists of a myristoylated N-terminal, seven putative tetratricopeptide repeats, a coiled-coil domain, the RING-H2 domain, and the consensus sequence for phosphorylation.

免疫原

whole purified rapsyn from Torpedo californica electric organ postsynaptic membrane.

應用

Monoclonal Anti-Rapsyn antibody produced in mouse has been used in western blotting (0.5 μg/ml ) and immunocytochemistry (1:200).

生化/生理作用

The receptor-associated protein of the synapse (RAPSYN) participates in assembling the structure of the nicotinic postsynaptic membrane. It is required for the functioning of the neuromuscular junction. Mutations in the RAPSN gene are associated with endplate acetylcholine-receptor deficiency and Myasthenic syndrome.

外觀

Solution in phosphate buffered saline containing 1.0 mg/mL BSA and 0.05% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品?  

试试我们的产品选型工具.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本?

如果您需要特殊版本,可通过批号或批次号查找具体证书。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Glen B Banks et al.
Journal of neurocytology, 32(5-8), 709-726 (2004-03-23)
Neuromuscular synapse formation is brought about by a complex bi-directional exchange of information between the innervating motor neuron and its target skeletal muscle fiber. Agrin, a heparin sulfate proteoglycan, is released from the motor nerve terminal to activate its muscle-specific
Marianna Rodova et al.
Molecular and cellular biology, 24(16), 7188-7196 (2004-07-30)
Rapsyn is a synapse-specific protein that is required for clustering acetylcholine receptors at the neuromuscular junction. Analysis of the rapsyn promoter revealed a consensus site for the transcription factor Kaiso within a region that is mutated in a subset of
S A Eckler et al.
Neuroscience, 131(3), 661-670 (2005-02-26)
The peripheral muscle membrane protein rapsyn is essential for the formation and maintenance of high density acetylcholine receptor aggregates at the neuromuscular synapse. Rapsyn is concentrated at synaptic sites and is colocalized with acetylcholine receptors from the earliest stages of
Benoît Zuber et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(26), 10622-10627 (2013-06-12)
The scaffolding protein at the neuromuscular junction, rapsyn, enables clustering of nicotinic acetylcholine receptors in high concentration and is critical for muscle function. Patients with insufficient receptor clustering suffer from muscle weakness. However, the detailed organization of the receptor-rapsyn network
Isabel Martinez-Pena y Valenzuela et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(43), 15586-15596 (2011-10-28)
α-Syntrophin (α-syn), a scaffold protein, links signaling molecules to the dystrophin-glycoprotein complex. Absence of α-syn from the DGC is known to lead to structurally aberrant neuromuscular junctions (NMJs) with few acetylcholine receptors (AChRs) clustered at synaptic sites. Using α-syn knock-out

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门