跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

R121

Sigma-Aldrich

S(−)-雷氯必利 (+)-酒石酸盐

>97%, solid

别名:

3,5-二氯-N-（1-乙基吡咯烷-2-基甲基）-2-羟基-6-甲氧基苯甲酰胺 (+)-酒石酸盐

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C15H20Cl2N2O3 · C4H6O6
CAS号:
98185-20-7
分子量:
497.32
MDL號碼:
MFCD00274072
分類程式碼代碼:
12352200
PubChem物質ID:
24277931
NACRES:
NA.77

品質等級

100

化驗

>97%

形狀

solid

顏色

white

溶解度

H2O: 89 mg/mL

SMILES 字串

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC

InChI

1S/C15H20Cl2N2O3.C4H6O6/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2;5-1(3(7)8)2(6)4(9)10/h7,9,20H,3-6,8H2,1-2H3,(H,18,21);1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

InChI 密鑰

QULBVRZTKPQGCR-NDAAPVSOSA-N

基因資訊

human ... DRD2(1813)

應用

S(−)-雷氯必利(+)-酒石酸盐已用作D2 受体拮抗剂：
  • 研究D2受体在介导动物PAG腹外侧区(vlPAG)/背侧中缝多巴胺能镇痛中的作用
  • Thap1缺失小鼠药理学和行为研究
  • 测定Ca2+瞬变与大鼠多巴胺神经元活性之间的关系

生化／生理作用

雷氯必利是一种苯甲酰胺衍生物和选择性D2多巴胺受体拮抗剂。

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

注意

光敏性

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCC6896
BCBW8974
BCBS7358
BCBQ6483V
BCBQ6483

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

J Kopp et al.
Neuroscience, 47(4), 771-779 (1992-01-01)
Prolonged treatment with dopamine D2 receptor antagonists is known to elevate the density of dopamine D2 receptor binding sites in caudate-putamen and nucleus accumbens in rat and human brain. In this study we used the dopamine D2 receptor antagonist raclopride
Angel Toval et al.
Molecular neurobiology, 58(4), 1782-1791 (2021-01-05)
Improving exercise capacity during adolescence impacts positively on cognitive and motor functions. However, the neural mechanisms contributing to enhance physical performance during this sensitive period remain poorly understood. Such knowledge could help to optimize exercise programs and promote a healthy
P Protais et al.
European journal of pharmacology, 271(1), 167-177 (1994-12-12)
S 14506 (1-[-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piper azine hydrochloride), 8-OH-DPAT ((+/-)-8-hydroxydipropylaminotetralin hydrobromide), clozapine and raclopride were compared in some behavioural models able to characterize dopamine antagonist properties. In mice treated with apomorphine (0.75 mg/kg, s.c.), stereotyped climbing and sniffing were dose dependently antagonized by
H Lublin et al.
Psychopharmacology, 112(2-3), 389-397 (1993-01-01)
The effects of chronic treatment with dopamine (DA) D1 and D2 receptor antagonists were evaluated in eight cebus apella monkeys with mild oral dyskinesia after previous haloperidol treatment. SCH 23390 (D1 antagonist) was given daily to investigate the direct behavioural
Andrew G Yee et al.
Journal of neurochemistry, 148(4), 462-479 (2018-09-12)
Despite the importance of somatodendritic dopamine (DA) release in the Substantia Nigra pars compacta (SNc), its mechanism remains poorly understood. Using a novel approach combining fast-scan controlled-adsorption voltammetry (FSCAV) and single-unit electrophysiology, we have investigated the mechanism of somatodendritic release

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门