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形狀
powder
顏色
white
溶解度
methanol: >10 mg/mL
DMSO: >10.1 mg/mL
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
dilute aqueous base: insoluble
SMILES 字串
CC1=C(CCN2CCC(\CC2)=C(\c3ccc(F)cc3)c4ccc(F)cc4)C(=O)N5C=CSC5=N1
InChI
1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3
InChI 密鑰
JUQLTPCYUFPYKE-UHFFFAOYSA-N
基因資訊
human ... HTR2A(3356)
rat ... Adra1a(29412) , Drd2(24318) , Htr1a(24473) , Htr2a(29595) , Htr7(65032)
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應用
利坦色林已用于行为测试,并用作 5-羟色胺 2A 受体(5-HT2A)受体拮抗剂。
生化/生理作用
利坦色林是有效的 5-羟色胺 2A 受体(5-HT2A)羟色胺受体拮抗剂/反向激动剂,可穿过血脑屏障。它调节 5-HT 2A 受体,并被认为具有抗帕金森作用。利坦色林还通过调节情绪、认知和消极症状来影响精神分裂症。
有效的 5-HT2A 5-羟色胺受体拮抗剂/反向激动剂,可穿越血脑屏障。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Does ritanserin, a potent serotonin-S2 antagonist, restore energetic functions during the night?
Journal of the Royal Society of Medicine, 80, 409-413 (1987)
The 5-HT 2 antagonist ritanserin blocks dopamine re-uptake in the rat frontal cortex
Molecular Psychiatry, 5(6), 673-673 (2000)
Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone
Journal of Neurochemistry, 110(2), 595-602 (2009)
Modulation by 5-HT2A receptors of aggressive behavior in isolated mice
Japanese Journal of Pharmacology, 89(1), 89-92 (2002)
The Journal of pharmacology and experimental therapeutics, 334(3), 1066-1074 (2010-06-22)
Behavioral studies show that modulation of the glutamatergic system might be an efficient way to achieve antidepressant activity. Among the group III metabotropic glutamate (mGlu) receptors, the mGlu7 receptor subtype seems to be the most promising target for potential antidepressants.
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