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Merck
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Key Documents

PZ0328

Sigma-Aldrich

PF-4800567 hydrochloride

≥98% (HPLC)

别名:

3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride, PF 4800567

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About This Item

经验公式(希尔记法):
C17H18ClN5O2 · HCl
分子量:
396.27
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear (warmed)

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C17H18ClN5O2.ClH/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12;/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21);1H

InChI 密鑰

QZXZQMUZEHTFHD-UHFFFAOYSA-N

生化/生理作用

PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) that is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocation, but does not effect the circadian clock in animal studies.
PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl.

其他說明

PF-4800567 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the PF-4800567 probe summary on the Chemical Probes Portal website.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Patton AP, et al.
The Journal of Neuroscience, 36(36), 9326-9341 (2016)

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