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Merck
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Key Documents

PZ0315

Sigma-Aldrich

芦平曲韦

≥98% (HPLC)

别名:

AG-7088, AG7088, 乙基 (E,4S)-4-[[(2R,5S)-2-[(4-氟苯基)甲基] -6-甲基-5-[(5-甲基-1,2-恶唑-3-羰基)氨基]-4-氧代庚酰基]氨基] -5-[(3S)-2-氧吡咯烷-3-基]戊-2-烯酸酯, 芦平曲韦

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About This Item

经验公式（希尔记法）:
C31H39FN4O7
CAS号:
223537-30-2
分子量:
598.66
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +30 to +40°, c = 0.5 in chloroform-d

顏色

white to beige

溶解度

DMSO: 25 mg/mL, clear

儲存溫度

room temp

InChI

1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1

InChI 密鑰

CAYJBRBGZBCZKO-BHGBQCOSSA-N

一般說明

芦平曲韦是一种不可逆的拟肽抑制剂，其可靶向人鼻病毒（HRV）。其之前被命名为AG7088。芦平曲韦也被发现可能涉及 体外 抗病毒活性。

生化／生理作用

芦平曲韦（AG7088）是一种不可逆的人类鼻病毒（HRV）3C蛋白酶抑制剂，其也被发现可以抑制肠病毒和诺如病毒。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Immune sensor proteins are critical to the function of the human innate immune system. The full repertoire of cognate triggers for human immune sensors is not fully understood. Here, we report that human NACHT, LRR, and PYD domains-containing protein 1
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