推荐产品
生物源
bovine plasma
品質等級
形狀
lyophilized powder
比活性
≥2.0 units/mg protein
濃度
2-7% protein (biuret)
適合性
not suitable for streptokinase determination by clot formation procedure
應用
histology
儲存溫度
2-8°C
基因資訊
cow ... PLG(280897)
human ... PLG(5340)
生化／生理作用
The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling.
纤溶酶原是蛋白酶纤溶酶的无活性前体。纤溶酶原由组织型纤溶酶原激活剂 (tPA) 激活，tPA 主要激活纤溶酶的纤维蛋白溶解（血栓溶解）活性，或者由尿激酶型纤溶酶原激活剂 (uPA) 激活，uPA 与细胞外基质重塑和细胞迁移有关。纤溶酶可裂解纤维蛋白/纤维蛋白原和凝血因子 V/Va 以及 VIII/VIIIa。它可通过裂解非活性酶原激活基质金属蛋白酶。还与某些生长因子的激活有关，如血管內皮生長因子 (VEGF) 和转化生长因子 β (TGF-β)。
其他說明
不含 ε-氨基己酸
單位定義
当测定 5.0mL 体积中的高氯酸可溶性产物时，在 pH 7.5 和 37°C 下，一单位本品将使 α-酪蛋白在 20 分钟内产生 1.0 的 ΔA275。活性在尿激酶激活纤溶酶后测定。
外觀
冻干粉，含 NaCl、EDTA、赖氨酸以及 Tris 缓冲盐
重構
溶液应储存在含 20mM 赖氨酸的中性 pH 缓冲液中。蛋白质应尽量浓缩。分成小份在 -20°C 下冻存，可稳定保存几周。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
L Chikahisa et al.
Invasion & metastasis, 17(6), 323-333 (1997-01-01)
Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the
Barbara Ruszkowska et al.
Acta obstetricia et gynecologica Scandinavica, 92(7), 841-846 (2013-03-12)
To assess the concentration of adiponectin, soluble E-selectin, soluble thrombomodulin and tissue activator plasminogen antigen in postmenopausal women who received oral or transdermal hormone therapy. Case-control study. Polish university hospitals. Seventy-six healthy postmenopausal women. Forty-six women who received oral (n
Lina Ma et al.
Se pu = Chinese journal of chromatography, 30(8), 822-826 (2012-12-22)
The Kringle 5 domain of plasminogen is one of the most potent angiogenesis inhibitors known to date, which can inhibit cell proliferation and migration efficiently. In the study, on the foundation of successful clone and expression of recombinant soluble and
Venous thrombosis in the nephrotic syndrome.
Joseph Loscalzo
The New England journal of medicine, 368(10), 956-958 (2013-03-08)
Yueling Zhang et al.
FEBS letters, 587(9), 1304-1309 (2013-03-12)
Cluster 1 streptokinases (SK1) from Streptococcus pyogenes (GAS) show substantially higher human plasminogen (hPg) activation activities and tighter hPg binding affinities than cluster 2b streptokinases (SK2b) in solution. The extent to which the different domains of SK are responsible for
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