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生物源
synthetic (organic)
化驗
≥98% (HPLC)
形狀
powder
mp
106-108 °C (lit.)
溶解度
ethanol: 50 mg/mL, clear, colorless to light yellow
SMILES 字串
CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
InChI
1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
InChI 密鑰
VYMDGNCVAMGZFE-UHFFFAOYSA-N
基因資訊
human ... CYP2C9(1559) , PTGIS(5740) , PTGS1(5742) , PTGS2(5743)
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應用
保泰松已被用于：
- 在转基因斑马鱼（LiPan）肝毒素测定中用作肝毒素
- 在高效液相色谱-紫外（HPLC-UV）中用作标准品
- 在鸡′蛋绒毛尿囊膜试验（HET-CAM试验）中用作抗炎化合物
生化／生理作用
保泰松是一种肝毒素，可与血浆蛋白结合。它可用于治疗马的炎症。保泰松具有治疗强直性脊柱炎的潜力。它可通过诱导肌盲样蛋白1（MBNL1）的表达而具有治疗I型强直性肌营养不良（DM1）的潜力。它还有利于骨骼肌中肌肉氯离子通道的表达。
基底
非甾体抗炎化合物；环氧合酶抑制剂，也是环氧合酶过氧化的底物。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
Chen G, et al.
Scientific Reports, 6, 25317-25317 (2016)
Amit Verma et al.
European journal of medicinal chemistry, 43(5), 897-905 (2007-09-18)
The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the 4-thiazolidinones in the present context and promise they hold for the future.
Phenylbutazone purity challenge
McRae G, et al.
Analytical and Bioanalytical Chemistry, 408(12), 3051-3053 (2016)
J H Foreman et al.
Equine veterinary journal. Supplement, (38)(38), 601-605 (2011-05-27)
Objective blinded efficacy data during exercise are lacking on the use of single-dose i.v. nonsteroidal anti-inflammatory drugs (NSAIDs) before, during and after exercise. Single i.v. doses of either phenylbutazone (PBZ) or flunixin meglumine (FM) would prove more efficacious than negative
J H Foreman et al.
Equine veterinary journal. Supplement, (40)(40), 12-17 (2011-12-07)
Using an adjustable heart bar shoe model of foot pain, the objective of this study was to test the hypothesis that the combined use of phenylbutazone (PBZ) and flunixin meglumine (FM) would prove more efficacious in alleviating lameness than either
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