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Merck

P7888

Sigma-Aldrich

DL-炔丙基甘氨酸

cystathionine γ-lyase inhibitor

别名:

2-氨基-4-戊炔酸, PAG

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About This Item

经验公式(希尔记法):
C5H7NO2
CAS号:
分子量:
113.11
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.26

品質等級

化驗

≥98% (TLC)

形狀

powder

顏色

white

應用

cell analysis

儲存溫度

−20°C

SMILES 字串

NC(CC#C)C(O)=O

InChI

1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)

InChI 密鑰

DGYHPLMPMRKMPD-UHFFFAOYSA-N

應用


  • Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.: This study demonstrates the enhanced antibacterial efficiency of a metabolic labeling strategy using ᴅʟ-Propargylglycine in photothermal and photodynamic therapy for treating bacteria-infected wounds (Li et al., 2022).

  • Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.: This research utilizes ᴅʟ-Propargylglycine for metabolic labeling, allowing near-infrared II imaging of gut microbiota in vivo, providing new insights into microbiome studies (Wang et al., 2020).

  • Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.: Investigates the role of ᴅʟ-Propargylglycine, in upregulating specific mRNA expressions in gastric mucosa, with implications for gastrointestinal research (Cheraghi et al., 2016).

生化/生理作用

DL-丙炔甘氨酸(PAG)是胱硫醚γ-裂解酶(GCL)的不可逆抑制剂,该酶是一种参与谷胱甘肽合成 和调节同型半胱氨酸浓度并介导半胱氨酸合成的代谢转硫途径的关键酶。利用PAG治疗动物疾病模型显示其可减轻破坏硫化氢(H2S)形成或作用的疾病的相关症状。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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Carolina P Lima et al.
The Journal of nutrition, 136(8), 2141-2147 (2006-07-22)
The transsulfuration pathway, which aids in regulating homocysteine concentration and mediates cysteine synthesis, may be sensitive to vitamin B-6 status because cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) require pyridoxal 5'-phosphate (PLP). To assess relations between vitamin B-6 and transsulfuration
Karen P Maruska et al.
The Journal of comparative neurology, 525(3), 610-638 (2016-08-11)
Neural communication depends on release and reception of different neurotransmitters within complex circuits that ultimately mediate basic biological functions. We mapped the distribution of glutamatergic, GABAergic, and cholinergic neurons in the brain of the African cichlid fish Astatotilapia burtoni using
Csaba Szabó
Nature reviews. Drug discovery, 6(11), 917-935 (2007-10-20)
Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling molecule in the cardiovascular and nervous systems. The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase. Evidence is accumulating to demonstrate
Mercedes Tkach et al.
The EMBO journal, 36(20), 3012-3028 (2017-09-20)
Exosomes, nano-sized secreted extracellular vesicles (EVs), are actively studied for their diagnostic and therapeutic potential. In particular, exosomes secreted by dendritic cells (DCs) have been shown to carry MHC-peptide complexes allowing efficient activation of T lymphocytes, thus displaying potential as
Lambert Nzungize et al.
Journal of drug targeting, 27(9), 1004-1016 (2019-02-08)
Tuberculosis, especially multidrug resistant cases, remains an enormous public health threat. Mycobacterium tuberculosis metC (Rv3340) an enzyme involved in methionine biosynthesis was identified and characterised for antimicrobial susceptibility. We reported that the overexpression of Rv3340 in Mycobacterium smegmatis (Ms_Rv3340) produces

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