P5333

Pleiotrophin human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

• 别名: HARP, HB-GAM, Heparin affinity regulatory peptide, Heparin-binding growth factor, Heparin-binding growth-associated molecule, PTN
• MDL號碼: MFCD01324256
• 分類程式碼代碼: 12352202
• NACRES: NA.32

属性

• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 化驗: ≥97% (SDS-PAGE)
• 形狀: lyophilized powder
• 分子量: predicted mol wt 15.3 kDa
• 包裝: pkg of 50 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 技術: cell culture | mammalian: suitable
• 雜質: endotoxin, tested
• UniProt登錄號: P21246
• 儲存溫度: −20°C
• 基因資訊: human ... PTN(5764)

说明

一般說明

Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). This gene is highly expressed in brain, uterus, gut, muscle, lung and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, tumor cells, fibroblasts, astrocytes and Schwann cells.

應用

PTN is active in growth and development, and has mitogenic and neurite outgrowth activity. The gene for pleiotrophin is highly expressed in brain, uterus, gut, muscle, lung, and skin tissues

生化／生理作用

Pleiotrophin participates in growth and development. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

Pleiotrophin may be the first member of a family of developmentally regulated cytokines. It is active in growth and development and the pleiotrophin gene is highly expressed in brain, uterus, gut, muscle, lung, and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, fibroblasts, astrocytes, Schwann cells, and tumor cells. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

分析報告

The activity is measured in culture by the ability to enhance neurite outgrowth of cerebral cortical neurons from rat embryos.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)