推荐产品
形狀
solid
品質等級
顏色
white
溶解度
H2O: ≥43 mg/mL, colorless to almost colorless
起源
Sanofi Aventis
SMILES 字串
CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
InChI
1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
InChI 密鑰
MQGNNJQTNFHNHK-UHFFFAOYSA-N
基因資訊
human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124)
rat ... Tnf(24835)
正在寻找类似产品? 访问 产品对比指南
應用
Pentoxifylline has been used:
- used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
- to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
- to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour
生化/生理作用
Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.
Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).
特點和優勢
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Lact.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons
Journal of clinical medicine, 8(3), 287-287 (2019)
The American journal of physiology, 277(4 Pt 1), G847-G854 (1999-10-12)
Although the ability of nonsteriodal anti-inflammatory drugs (NSAIDs) to injure the small intestine has been well established in humans and animals, the mechanism involved in this type of injury has yet to be elucidated. The cytokine tumor necrosis factor-alpha (TNF-alpha)
PP-023-Effect of ICSI with `pentoxifylline exposed sperms? on subsequent embryo development
Reproductive Biomedicine Online, 32, S11-S11 (2016)
Pentoxifylline Enhances the Apoptotic Effect of Carboplatin in Y79 Retinoblastoma Cells
In Vivo, 33(2), 401-412 (2019)
Combined itraconazole-pentoxifylline treatment promptly reduces lung fibrosis induced by chronic pulmonary paracoccidioidomycosis in mice
Pulmonary Pharmacology & Therapeutics, 24(1), 81-91 (2011)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门