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Merck

P0547

Sigma-Aldrich

喷他脒 羟乙基磺酸盐

powder

别名:

1,5-双( p -脒基苯氧基)戊烷双(2-羟乙磺酸盐), 4,4′-二苯甲脒双

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About This Item

线性分子式:
CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H
CAS号:
分子量:
592.68
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

形狀

powder

品質等級

mp

188-194 °C (lit.)

抗生素活性譜

fungi

作用方式

enzyme | inhibits

起源

Celgene

儲存溫度

−20°C

SMILES 字串

OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1

InChI

1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)

InChI 密鑰

YBVNFKZSMZGRAD-UHFFFAOYSA-N

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應用

卡氏肺囊虫抗菌药
异硫氰酸喷他脒盐已用于:
  • 作为抗利什曼原虫、抗疟原虫和细胞毒性试验的阳性对照
  • 作为原型化合物,分析抑制剂对人快速延迟性整流性相关基因 (HERG) K + 通道转运的影响
  • 作为前鞭毛体中的抗利什曼原虫药物

生化/生理作用

具有神经保护作用;抑制脑内组成型一氧化氮合酶;NMDA 谷氨酸受体拮抗剂。
羟乙基喷他脒作为利什曼病的二线药物。

特點和優勢

该化合物由 Celgene 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里

象形圖

Exclamation mark

訊號詞

Warning

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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